DegronMD - P19235(EPOR)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T466I	TCGA-61-2008	OV	TCGA	DSGIST	DEG_SCF_TRCP1_1	461:466	Mutation altering degron motif	0.7078
p.T466I	DO29658	OV	ICGC	DSGIST	DEG_SCF_TRCP1_1	461:466	Mutation altering degron motif	0.7078
p.E325D	TCGA-AP-A051	UCEC	TCGA	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.6758
p.E325D	DO42673	UCEC	ICGC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.6758
p.E325D	SIDM00094	Kidney Carcinoma	GDSC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.6758
p.E325D	ACH-002199	Kidney Cancer	CCLE	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.6758
p.E325D	SN12C	kidney	COSMIC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.6758
p.T324M	TCGA-AP-A1DO	UCEC	TCGA	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.6312
p.T324M	DO43250	UCEC	ICGC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.6312
p.T324M	SIDM00336	Melanoma	GDSC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.6312
p.T324M	ACH-000881	Skin Cancer	CCLE	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.6312
p.T324M	MEL-JUSO	skin	COSMIC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.6312
p.A329V	TCGA-DJ-A13X	THCA	TCGA	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation rewiring degron network	0.2222
p.A329V	DO39076	THCA	ICGC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation rewiring degron network	0.2222
p.S470L	TCGA-E2-A152	BRCA	TCGA	DSGIST	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.2222
p.S470L	DO4449	BRCA	ICGC	DSGIST	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.2222
p.L500M	TCGA-EW-A1IW	BRCA	TCGA	PPSY	ITCH	501:504	Mutation rewiring degron network	0.3056
p.L500M	DO5500	BRCA	ICGC	PPSY	ITCH	501:504	Mutation rewiring degron network	0.3056
p.L331M	TCGA-FS-A1Z0	SKCM	TCGA	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation rewiring degron network	0.1667
p.L331M	DO37431	SKCM	ICGC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation rewiring degron network	0.1667
p.G475E	TCGA-G2-A2EC	BLCA	TCGA	DSGIST	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.0833
p.G475E	DO651	BLCA	ICGC	DSGIST	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.0833
p.L457P	TCGA-KO-8413	KICH	TCGA	DSGIST	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.2222
p.L457P	DO220587	KICH	ICGC	DSGIST	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.2222
p.G475R	DO52512	EOPC	ICGC	DSGIST	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.0833
p.P323T	DO228952	LICA	ICGC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.7031
p.P312S	DO228969	LICA	ICGC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation rewiring degron network	0.1389
p.P327L	DO228972	LICA	ICGC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation rewiring degron network	0.2778
p.D472E	DO229009	LICA	ICGC	DSGIST	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.1667
p.D472E	DO229008	LICA	ICGC	DSGIST	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.1667
p.P327H	DO46424	OV	ICGC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation rewiring degron network	0.2778
p.P495T	DO229268	THCA	ICGC	PPSY	ITCH	501:504	Mutation rewiring degron network	0.1667
p.L321S	DO43306	UCEC	ICGC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.7667
p.A497T	SIDM00375	Head and Neck Carcinoma	GDSC	PPSY	ITCH	501:504	Mutation rewiring degron network	0.2222
p.A497T	ACH-002305	Head and Neck Cancer	CCLE	PPSY	ITCH	501:504	Mutation rewiring degron network	0.2222
p.A497T	SKN-3	upper aerodigestive tract	COSMIC	PPSY	ITCH	501:504	Mutation rewiring degron network	0.2222
p.P502R	SIDM01343	Gastric Carcinoma	GDSC	PPSY	ITCH	501:504	Mutation altering degron motif	0.7512
p.T321I	ACH-001539	Lymphoma	CCLE	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation altering degron motif	0.7078
p.P318L	MZ7-mel	skin	COSMIC	PCTPFTE	DEG_SCF_FBW7_2	319:325	Mutation rewiring degron network	0.3056

Kaplan plot for EPOR in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPOR

UniProt ID: P19235

Entrez ID: 2057

Protein name: Erythropoietin receptor (EPO-R)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for EPOR in