DegronMD

Uniprot ID: P19235

Source protein: Erythropoietin receptor

Source gene: EPOR

Class: DEG_SCF_FBW7_2

Location: 319:325

E3 ligase: FBXW7

DEGRON score: 0.7466

ASA_SCORE: 80.9714

COIL: 0.8167

CONS_SCORE: 0.5415

DSS_SCORE: 0.2422

HELIX: 0.04

FCONS_SCORE: 0.7459

RIG_SCORE: 0.8359

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E325D	TCGA-AP-A051	UCEC	TCGA	PCTPFTE	DEG_SCF_FBW7_2	0.6758
p.E325D	DO42673	UCEC	ICGC	PCTPFTE	DEG_SCF_FBW7_2	0.6758
p.E325D	SIDM00094	Kidney Carcinoma	GDSC	PCTPFTE	DEG_SCF_FBW7_2	0.6758
p.E325D	ACH-002199	Kidney Cancer	CCLE	PCTPFTE	DEG_SCF_FBW7_2	0.6758
p.E325D	SN12C	kidney	COSMIC	PCTPFTE	DEG_SCF_FBW7_2	0.6758
p.T324M	TCGA-AP-A1DO	UCEC	TCGA	PCTPFTE	DEG_SCF_FBW7_2	0.6312
p.T324M	DO43250	UCEC	ICGC	PCTPFTE	DEG_SCF_FBW7_2	0.6312
p.T324M	SIDM00336	Melanoma	GDSC	PCTPFTE	DEG_SCF_FBW7_2	0.6312
p.T324M	ACH-000881	Skin Cancer	CCLE	PCTPFTE	DEG_SCF_FBW7_2	0.6312
p.T324M	MEL-JUSO	skin	COSMIC	PCTPFTE	DEG_SCF_FBW7_2	0.6312
p.A329V	TCGA-DJ-A13X	THCA	TCGA	PCTPFTE	DEG_SCF_FBW7_2	0.2222
p.A329V	DO39076	THCA	ICGC	PCTPFTE	DEG_SCF_FBW7_2	0.2222
p.L331M	TCGA-FS-A1Z0	SKCM	TCGA	PCTPFTE	DEG_SCF_FBW7_2	0.1667
p.L331M	DO37431	SKCM	ICGC	PCTPFTE	DEG_SCF_FBW7_2	0.1667
p.P323T	DO228952	LICA	ICGC	PCTPFTE	DEG_SCF_FBW7_2	0.7031
p.P312S	DO228969	LICA	ICGC	PCTPFTE	DEG_SCF_FBW7_2	0.1389
p.P327L	DO228972	LICA	ICGC	PCTPFTE	DEG_SCF_FBW7_2	0.2778
p.P327H	DO46424	OV	ICGC	PCTPFTE	DEG_SCF_FBW7_2	0.2778
p.L321S	DO43306	UCEC	ICGC	PCTPFTE	DEG_SCF_FBW7_2	0.7667
p.T321I	ACH-001539	Lymphoma	CCLE	PCTPFTE	DEG_SCF_FBW7_2	0.7078
p.P318L	MZ7-mel	skin	COSMIC	PCTPFTE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19235	Erythropoietin receptor	DEG_SCF_FBW7_2	319:325	PCTPFTE	FBXW7	0.7466	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons