DegronMD

Uniprot ID: P19235

Source protein: Erythropoietin receptor

Source gene: EPOR

Class: DEG_SCF_TRCP1_1

Location: 461:466

E3 ligase: BTRC

DEGRON score: 0.9755

ASA_SCORE: 47.4333

COIL: 0.729

CONS_SCORE: 0.7847

DSS_SCORE: 0.3039

HELIX: 0.0502

FCONS_SCORE: 1.313

RIG_SCORE: 0.7022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T466I	TCGA-61-2008	OV	TCGA	DSGIST	DEG_SCF_TRCP1_1	0.7078
p.T466I	DO29658	OV	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.7078
p.S470L	TCGA-E2-A152	BRCA	TCGA	DSGIST	DEG_SCF_TRCP1_1	0.2222
p.S470L	DO4449	BRCA	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.2222
p.G475E	TCGA-G2-A2EC	BLCA	TCGA	DSGIST	DEG_SCF_TRCP1_1	0.0833
p.G475E	DO651	BLCA	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.0833
p.L457P	TCGA-KO-8413	KICH	TCGA	DSGIST	DEG_SCF_TRCP1_1	0.2222
p.L457P	DO220587	KICH	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.2222
p.G475R	DO52512	EOPC	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.0833
p.D472E	DO229009	LICA	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.1667
p.D472E	DO229008	LICA	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19235	Erythropoietin receptor	DEG_SCF_TRCP1_1	461:466	DSGIST	BTRC	0.9755	More...
Q8NHS9	Spermatogenesis-associated protein 22	DEG_SCF_TRCP1_1	40:45	DSGIST	BTRC	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons