DegronMD - Q8NHS9(SPATA22)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L37I	TCGA-3A-A9IV	PAAD	TCGA	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.25
p.L37I	DO218959	PAAD	ICGC	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.25
p.N35D	TCGA-AA-A00N	COAD	TCGA	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.1944
p.N35D	DO9876	COAD	ICGC	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.1944
p.K38E	TCGA-BS-A0UV	UCEC	TCGA	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.2778
p.K38E	DO42793	UCEC	ICGC	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.2778
p.S41L	TCGA-D1-A17N	UCEC	TCGA	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation altering degron motif	0.7667
p.S41L	DO41410	UCEC	ICGC	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation altering degron motif	0.7667
p.D51N	TCGA-YD-A89C	SKCM	TCGA	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.1667
p.D51N	DO219501	SKCM	ICGC	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.1667
p.D48E	DO229022	LICA	ICGC	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.25
p.P54L	SIDM00150	Colorectal Carcinoma	GDSC	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.0833
p.P54L	ACH-000969	Colon/Colorectal Cancer	CCLE	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.0833
p.P54L	KM12	large intestine	COSMIC	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.0833
p.N49I	ACH-000429	Kidney Cancer	CCLE	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.2222
p.R46I	HT-115	large intestine	COSMIC	DSGIST	DEG_SCF_TRCP1_1	40:45	Mutation rewiring degron network	0.3056

Kaplan plot for SPATA22 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA22

UniProt ID: Q8NHS9

Entrez ID: 84690

Protein name: Spermatogenesis-associated protein 22 (Testis development protein NYD-SP20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA22 in