DegronMD

Uniprot ID: Q8NHS9

Source protein: Spermatogenesis-associated protein 22

Source gene: SPATA22

Class: DEG_SCF_TRCP1_1

Location: 40:45

E3 ligase: BTRC

DEGRON score: 0.9966

ASA_SCORE: 61.3667

COIL: 0.937

CONS_SCORE: 0.3175

DSS_SCORE: 0.5974

HELIX: 0.0278

FCONS_SCORE: 0.5792

RIG_SCORE: 0.6241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L37I	TCGA-3A-A9IV	PAAD	TCGA	DSGIST	DEG_SCF_TRCP1_1	0.25
p.L37I	DO218959	PAAD	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.25
p.N35D	TCGA-AA-A00N	COAD	TCGA	DSGIST	DEG_SCF_TRCP1_1	0.1944
p.N35D	DO9876	COAD	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.1944
p.K38E	TCGA-BS-A0UV	UCEC	TCGA	DSGIST	DEG_SCF_TRCP1_1	0.2778
p.K38E	DO42793	UCEC	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.2778
p.S41L	TCGA-D1-A17N	UCEC	TCGA	DSGIST	DEG_SCF_TRCP1_1	0.7667
p.S41L	DO41410	UCEC	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.7667
p.D51N	TCGA-YD-A89C	SKCM	TCGA	DSGIST	DEG_SCF_TRCP1_1	0.1667
p.D51N	DO219501	SKCM	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.1667
p.D48E	DO229022	LICA	ICGC	DSGIST	DEG_SCF_TRCP1_1	0.25
p.P54L	SIDM00150	Colorectal Carcinoma	GDSC	DSGIST	DEG_SCF_TRCP1_1	0.0833
p.P54L	ACH-000969	Colon/Colorectal Cancer	CCLE	DSGIST	DEG_SCF_TRCP1_1	0.0833
p.P54L	KM12	large_intestine	COSMIC	DSGIST	DEG_SCF_TRCP1_1	0.0833
p.N49I	ACH-000429	Kidney Cancer	CCLE	DSGIST	DEG_SCF_TRCP1_1	0.2222
p.R46I	HT-115	large_intestine	COSMIC	DSGIST	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19235	Erythropoietin receptor	DEG_SCF_TRCP1_1	461:466	DSGIST	BTRC	0.9755	More...
Q8NHS9	Spermatogenesis-associated protein 22	DEG_SCF_TRCP1_1	40:45	DSGIST	BTRC	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons