DegronMD - Q15884(FAM189A2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E244K	TCGA-06-5416	GBM	TCGA	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.25
p.E244K	DO10880	GBM	ICGC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.25
p.P139L	TCGA-AN-A046	BRCA	TCGA	PPSY	ITCH	148:151	Mutation rewiring degron network	0.0833
p.P139L	DO1285	BRCA	ICGC	PPSY	ITCH	148:151	Mutation rewiring degron network	0.0833
p.S275N	TCGA-AX-A05Z	UCEC	TCGA	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation blocking phosphorylation signal	0.6389
p.S275N	DO40884	UCEC	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation blocking phosphorylation signal	0.6389
p.D138N	TCGA-AX-A2HC	UCEC	TCGA	PPSY	ITCH	148:151	Mutation rewiring degron network	0.0556
p.D138N	DO41572	UCEC	ICGC	PPSY	ITCH	148:151	Mutation rewiring degron network	0.0556
p.R264K	TCGA-CA-6717	COAD	TCGA	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.6126
p.R264K	DO8264	COAD	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.6126
p.D276Y	TCGA-MI-A75G	LIHC	TCGA	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1667
p.D276Y	DO49709	LIHC	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1667
p.R161L	TCGA-VS-A8Q9	CESC	TCGA	PPSY	ITCH	148:151	Mutation rewiring degron network	0.0556
p.R161L	DO51626	CESC	ICGC	PPSY	ITCH	148:151	Mutation rewiring degron network	0.0556
p.P239T	TCGA-VS-A9UP	CESC	TCGA	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.P239T	DO219737	CESC	ICGC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.P195L	TCGA-XS-A8TJ	CESC	TCGA	PPPY	ITCH	194:197	Mutation altering degron motif	0.7582
p.P195L	DO219746	CESC	ICGC	PPPY	ITCH	194:197	Mutation altering degron motif	0.7582
p.P195L	DO45157	LIRI	ICGC	PPPY	ITCH	194:197	Mutation altering degron motif	0.7582
p.A265T	DO233079	GACA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.6028
p.A265P	DO233868	GACA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.6392
p.A265D	DO233868	GACA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.6682
p.S262G	DO233941	GACA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.5882
p.D141Y	DO229031	LICA	ICGC	PPSY	ITCH	148:151	Mutation rewiring degron network	0.1389
p.V278L	DO229034	LICA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1111
p.R258L	DO229045	LICA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.2222
p.R258L	DO229045	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1389
p.G184C	DO229008	LICA	ICGC	PPPY	ITCH	194:197	Mutation rewiring degron network	0.0556
p.P239S	DO229459	SKCA	ICGC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.P160H	DO229268	THCA	ICGC	PPSY	ITCH	148:151	Mutation rewiring degron network	0.0833
p.I241M	DO229240	THCA	ICGC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.R161Q	DO229242	THCA	ICGC	PPSY	ITCH	148:151	Mutation rewiring degron network	0.0556
p.G200A	SIDM01649	Non-Cancerous	GDSC	PPPY	ITCH	194:197	Mutation rewiring degron network	0.25
p.L243M	SIDM00680	Colorectal Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.2222
p.L243M	LS-180	large intestine	COSMIC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.2222
p.L141F	SIDM00654	Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	148:151	Mutation rewiring degron network	0.1389
p.L141F	SIDM00068	Colorectal Carcinoma	GDSC	PPSY	ITCH	148:151	Mutation rewiring degron network	0.1389
p.L243P	SIDM00660	Colorectal Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.2222
p.L243P	LS-411N	large intestine	COSMIC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.2222
p.C254F	SIDM00263	Ewing's Sarcoma	GDSC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1111
p.C254F	SIDM00263	Ewing's Sarcoma	GDSC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.25
p.C254F	ES5	bone	COSMIC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.1111
p.C254F	ES5	bone	COSMIC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.25
p.R261C	SIDM00282	Colorectal Carcinoma	GDSC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.3056
p.R261C	SIDM00282	Colorectal Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.0556
p.R261C	CW-2	large intestine	COSMIC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.3056
p.R261C	CW-2	large intestine	COSMIC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.0556
p.A280T	SIDM00837	Colorectal Carcinoma	GDSC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.0556
p.A280T	SW48	large intestine	COSMIC	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation rewiring degron network	0.0556
p.I241T	ACH-000227	Neuroblastoma	CCLE	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.I241T	ACH-000823	Esophageal Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.I241T	ACH-000843	Lung Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.I241T	ACH-000847	Gastric Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.I241T	ACH-000978	Endometrial/Uterine Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.I241T	ACH-001515	Cervical Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.I241T	ACH-001863	Bile Duct Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.I241T	ACH-002069	Bone Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.I241T	KYSE-140	oesophagus	COSMIC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.I241T	HARA	lung	COSMIC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.I241T	HGC-27	stomach	COSMIC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.I241T	KP-N-YN	autonomic ganglia	COSMIC	ASTST	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.D205N	ACH-000305	Esophageal Cancer	CCLE	PPPY	ITCH	194:197	Mutation rewiring degron network	0.1111
p.D205N	EC-GI-10	oesophagus	COSMIC	PPPY	ITCH	194:197	Mutation rewiring degron network	0.1111
p.P144T	ACH-000842	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	148:151	Mutation rewiring degron network	0.2222
p.D205E	ACH-002295	Head and Neck Cancer	CCLE	PPPY	ITCH	194:197	Mutation rewiring degron network	0.1111
p.D205E	PCI-30	upper aerodigestive tract	COSMIC	PPPY	ITCH	194:197	Mutation rewiring degron network	0.1111
p.R263W	ACH-002306	Gastric Cancer	CCLE	SRRALPPLR	DEG_APCC_DBOX_1	262:270	Mutation altering degron motif	0.8634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM189A2

UniProt ID: Q15884

Entrez ID: 9413

Protein name: Protein FAM189A2 (Protein X123)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM189A2 in