DegronMD

Uniprot ID: Q15884

Source protein: Protein FAM189A2

Source gene: FAM189A2

Class: DEG_APCC_DBOX_1

Location: 262:270

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.982

ASA_SCORE: 94.1

COIL: 0.8842

CONS_SCORE: 0.5561

DSS_SCORE: 0.6003

HELIX: 0.0752

FCONS_SCORE: 1.1361

RIG_SCORE: 0.6649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S275N	TCGA-AX-A05Z	UCEC	TCGA	SRRALPPLR	DEG_APCC_DBOX_1	0.6389
p.S275N	DO40884	UCEC	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	0.6389
p.R264K	TCGA-CA-6717	COAD	TCGA	SRRALPPLR	DEG_APCC_DBOX_1	0.6126
p.R264K	DO8264	COAD	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	0.6126
p.D276Y	TCGA-MI-A75G	LIHC	TCGA	SRRALPPLR	DEG_APCC_DBOX_1	0.1667
p.D276Y	DO49709	LIHC	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	0.1667
p.A265T	DO233079	GACA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	0.6028
p.A265P	DO233868	GACA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	0.6392
p.A265D	DO233868	GACA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	0.6682
p.S262G	DO233941	GACA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	0.5882
p.V278L	DO229034	LICA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	0.1111
p.R258L	DO229045	LICA	ICGC	SRRALPPLR	DEG_APCC_DBOX_1	0.2222
p.C254F	SIDM00263	Ewing's Sarcoma	GDSC	SRRALPPLR	DEG_APCC_DBOX_1	0.1111
p.C254F	ES5	bone	COSMIC	SRRALPPLR	DEG_APCC_DBOX_1	0.1111
p.R261C	SIDM00282	Colorectal Carcinoma	GDSC	SRRALPPLR	DEG_APCC_DBOX_1	0.3056
p.R261C	CW-2	large_intestine	COSMIC	SRRALPPLR	DEG_APCC_DBOX_1	0.3056
p.A280T	SIDM00837	Colorectal Carcinoma	GDSC	SRRALPPLR	DEG_APCC_DBOX_1	0.0556
p.A280T	SW48	large_intestine	COSMIC	SRRALPPLR	DEG_APCC_DBOX_1	0.0556
p.R263W	ACH-002306	Gastric Cancer	CCLE	SRRALPPLR	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15884	Protein FAM189A2	DEG_APCC_DBOX_1	262:270	SRRALPPLR	APC,CDC20,FZR1	0.982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons