DegronMD - A6NL88(SHISA7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R244Q	TCGA-A2-A25B	BRCA	TCGA	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.6218
p.R244Q	DO2706	BRCA	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.6218
p.P305T	TCGA-AP-A0LM	UCEC	TCGA	PPSY	ITCH	305:308	Mutation altering degron motif	0.7031
p.P305T	DO43306	UCEC	ICGC	PPSY	ITCH	305:308	Mutation altering degron motif	0.7031
p.T238S	TCGA-CK-4951	COAD	TCGA	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1944
p.T238S	DO10582	COAD	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1944
p.P236S	TCGA-DF-A2KZ	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1389
p.P236S	DO52409	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1389
p.P250L	TCGA-EO-A3L0	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.25
p.P250L	DO219775	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.25
p.D256N	TCGA-FI-A2D5	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.D256N	DO228660	PRAD	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.D256N	DO41331	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.P236H	TCGA-FI-A2D5	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1389
p.P236H	DO41331	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1389
p.G237V	DO223114	ESCA	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1667
p.G235V	DO228627	GACA	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1111
p.R239H	DO233823	GACA	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.2222
p.R239H	DO228142	PBCA	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.2222
p.S297Y	DO228976	LICA	ICGC	PPSY	ITCH	305:308	Mutation rewiring degron network	0.1111
p.T238N	DO228976	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1944
p.P306Q	DO229027	LICA	ICGC	PPSY	ITCH	305:308	Mutation altering degron motif	0.7035
p.D241E	DO229027	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.2778
p.S245R	DO229045	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.8538
p.L316P	DO229058	LICA	ICGC	PPSY	ITCH	305:308	Mutation rewiring degron network	0.1111
p.A234S	DO50736	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.G253S	SIDM02013	Colorectal Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1667
p.Q233E	SIDM00270	Head and Neck Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0556
p.Q233E	ACH-002294	Head and Neck Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0556
p.Q233E	PCI-15A	upper aerodigestive tract	COSMIC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0556
p.P255S	SIDM00082	Melanoma	GDSC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1111
p.P255S	ACH-001190	Skin Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1111
p.G251E	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.2222
p.G251E	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.2222
p.R318G	ACH-001278	Ovarian Cancer	CCLE	PPSY	ITCH	305:308	Mutation rewiring degron network	0.0556
p.T238P	D-423MG	central nervous system	COSMIC	ARSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1944

Kaplan plot for SHISA7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHISA7

UniProt ID: A6NL88

Entrez ID: 729956

Protein name: Protein shisa-7 (Cystine-knot AMPAR modulating protein of 59 kDa) (CKAMP59) (GABA(A) receptor auxiliary subunit Shisa7) (Protein shisa-6-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHISA7 in