DegronMD

Uniprot ID: A6NL88

Source protein: Protein shisa-7

Source gene: SHISA7

Class: DEG_SPOP_SBC_1

Location: 243:247

E3 ligase: SPOP

DEGRON score: 0.8952

ASA_SCORE: 68.56

COIL: 0.7898

CONS_SCORE: 0.4782

DSS_SCORE: 0.7662

HELIX: 0.1044

FCONS_SCORE: 0.832

RIG_SCORE: 0.5995

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R244Q	TCGA-A2-A25B	BRCA	TCGA	ARSSS	DEG_SPOP_SBC_1	0.6218
p.R244Q	DO2706	BRCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.6218
p.T238S	TCGA-CK-4951	COAD	TCGA	ARSSS	DEG_SPOP_SBC_1	0.1944
p.T238S	DO10582	COAD	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1944
p.P236S	TCGA-DF-A2KZ	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.1389
p.P236S	DO52409	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1389
p.P250L	TCGA-EO-A3L0	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.25
p.P250L	DO219775	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.25
p.D256N	TCGA-FI-A2D5	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.0833
p.D256N	DO228660	PRAD	ICGC	ARSSS	DEG_SPOP_SBC_1	0.0833
p.D256N	DO41331	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.0833
p.P236H	TCGA-FI-A2D5	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.1389
p.P236H	DO41331	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1389
p.G237V	DO223114	ESCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1667
p.G235V	DO228627	GACA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1111
p.R239H	DO233823	GACA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.2222
p.R239H	DO228142	PBCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.2222
p.T238N	DO228976	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1944
p.D241E	DO229027	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.2778
p.S245R	DO229045	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.8538
p.A234S	DO50736	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.0833
p.G253S	SIDM02013	Colorectal Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.1667
p.Q233E	SIDM00270	Head and Neck Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.0556
p.Q233E	ACH-002294	Head and Neck Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	0.0556
p.Q233E	PCI-15A	upper_aerodigestive_tract	COSMIC	ARSSS	DEG_SPOP_SBC_1	0.0556
p.P255S	SIDM00082	Melanoma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.1111
p.P255S	ACH-001190	Skin Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	0.1111
p.G251E	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.2222
p.G251E	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	0.2222
p.T238P	D-423MG	central_nervous_system	COSMIC	ARSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NL88	Protein shisa-7	DEG_SPOP_SBC_1	243:247	ARSSS	SPOP	0.8952	More...
O43918	Autoimmune regulator	DEG_SPOP_SBC_1	246:250	ARSSS	SPOP	0.8679	More...
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_SPOP_SBC_1	395:399	ARSSS	SPOP	0.9781	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	533:537	ARSSS	SPOP	0.6596	More...
P08047	Transcription factor Sp1	DEG_SPOP_SBC_1	38:42	ARSSS	SPOP	0.9685	More...
P0C1S8	Wee1-like protein kinase 2	DEG_SPOP_SBC_1	553:557	ARSSS	SPOP	0.9215	More...
P10109	Adrenodoxin, mitochondrial	DEG_SPOP_SBC_1	59:63	ARSSS	SPOP	0.9801	More...
P41594	Metabotropic glutamate receptor 5	DEG_SPOP_SBC_1	1048:1052	ARSSS	SPOP	0.9696	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	994:998	ARSSS	SPOP	0.9945	More...
Q14721	Potassium voltage-gated channel subfamily B member 1	DEG_SPOP_SBC_1	515:519	ARSSS	SPOP	0.707	More...
Q5VWQ8	Disabled homolog 2-interacting protein	DEG_SPOP_SBC_1	724:728	ARSSS	SPOP	0.8774	More...
Q7Z591	Microtubule organization protein AKNA	DEG_SPOP_SBC_1	1157:1161	ARSSS	SPOP	0.9961	More...
Q86YJ5	E3 ubiquitin-protein ligase MARCHF9	DEG_SPOP_SBC_1	329:333	ARSSS	SPOP	0.8149	More...
Q86Z20	Coiled-coil domain-containing protein 125	DEG_SPOP_SBC_1	5:9	ARSSS	SPOP	0.7355	More...
Q8NCE2	Myotubularin-related protein 14	DEG_SPOP_SBC_1	510:514	ARSSS	SPOP	0.7067	More...
Q96AY4	Tetratricopeptide repeat protein 28	DEG_SPOP_SBC_1	2237:2241	ARSSS	SPOP	0.9436	More...
Q96S55	ATPase WRNIP1	DEG_SPOP_SBC_1	129:133	ARSSS	SPOP	0.9833	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	502:506	ARSSS	SPOP	0.9877	More...
Q9H773	dCTP pyrophosphatase 1	DEG_SPOP_SBC_1	134:138	ARSSS	SPOP	0.8753	More...
Q9NP85	Podocin	DEG_SPOP_SBC_1	5:9	ARSSS	SPOP	0.843	More...
Q9P246	Stromal interaction molecule 2	DEG_SPOP_SBC_1	507:511	ARSSS	SPOP	0.9992	More...
Q9UPN4	Centrosomal protein of 131 kDa	DEG_SPOP_SBC_1	142:146	ARSSS	SPOP	0.9791	More...
Q9Y6R9	Centrosomal protein CCDC61	DEG_SPOP_SBC_1	313:317	ARSSS	SPOP	0.8882	More...
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_SPOP_SBC_1	287:291	ARSSS	SPOP	0.9364	More...
Q92610	Zinc finger protein 592	DEG_SPOP_SBC_1	953:957	ARSSS	SPOP	0.8742	More...
A6NNA2	Serine/arginine repetitive matrix protein 3	DEG_SPOP_SBC_1	426:430	ARSSS	SPOP	0.73	More...
B2RC85	Radial spoke head 10 homolog B2	DEG_SPOP_SBC_1	693:697	ARSSS	SPOP	0.9652	More...
E7EW31	Proline-rich basic protein 1	DEG_SPOP_SBC_1	782:786	ARSSS	SPOP	0.9376	More...
P0C881	Radial spoke head 10 homolog B	DEG_SPOP_SBC_1	693:697	ARSSS	SPOP	0.9698	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	475:479	ARSSS	SPOP	0.6316	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSSS

Degron related mutations and impact score

Drug responses associated with SHISA7 mutations

All proteins holding degron of ARSSS