DegronMD - Q96S55(WRNIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S436G	TCGA-13-1477	OV	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation blocking phosphorylation signal	0.6667
p.G438S	TCGA-A5-A2K7	UCEC	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation rewiring degron network	0.2778
p.A440T	TCGA-AA-3811	COAD	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation altering degron motif	0.6028
p.G446R	TCGA-AP-A051	UCEC	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation altering degron motif	0.6457
p.A433T	TCGA-CV-6953	HNSC	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation rewiring degron network	0.1389
p.A433V	TCGA-EE-A2MD	SKCM	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation rewiring degron network	0.1389
p.T120A	DO8858	COAD	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0833
p.A129T	DO233284	GACA	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7139
p.N132D	DO233641	GACA	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.6932
p.M126I	DO229015	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.25
p.M126I	DO41764	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.25
p.R140L	DO229035	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1389
p.W137L	DO229041	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation substituting flanking lysine	0.3333
p.P127S	DO229465	SKCA	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.P127S	ACH-000803	Lung Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.E143K	DO37416	SKCM	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0556
p.A133T	DO40978	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7139
p.A133T	NCI-H2085	lung	COSMIC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7139
p.R127W	DO43306	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.R127W	DO223286	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.S456N	SIDM00386	Ewing's Sarcoma	GDSC	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation rewiring degron network	0.1111
p.S456N	SIDM00482	Chronic Myelogenous Leukemia	GDSC	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation rewiring degron network	0.1111
p.S456N	SIDM00056	Thyroid Gland Carcinoma	GDSC	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation rewiring degron network	0.1111
p.R458S	SIDM00261	Ewing's Sarcoma	GDSC	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation rewiring degron network	0.0556
p.R458S	ACH-002109	Bone Cancer	CCLE	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation rewiring degron network	0.0556
p.R458S	ES8	bone	COSMIC	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation rewiring degron network	0.0556
p.R130H	SIDM01622	Breast Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7133
p.R130H	ACH-000721	Breast Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7133
p.T120S	WM278	skin	COSMIC	ARSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0833
p.R433S	ES8	bone	COSMIC	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation rewiring degron network	0.1389
p.E458G	ONS-76	central nervous system	COSMIC	ARAGLNGLQ	DEG_APCC_DBOX_1	440:448	Mutation rewiring degron network	0.0556

Kaplan plot for WRNIP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WRNIP1

UniProt ID: Q96S55

Entrez ID: 56897

Protein name: ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WRNIP1 in