DegronMD

Uniprot ID: Q96S55

Source protein: ATPase WRNIP1

Source gene: WRNIP1

Class: DEG_APCC_DBOX_1

Location: 440:448

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6859

ASA_SCORE: 9.1556

COIL: 0.0216

CONS_SCORE: 0.6919

DSS_SCORE: 0.1179

HELIX: 0.9761

FCONS_SCORE: 1.6099

RIG_SCORE: 0.7959

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S436G	TCGA-13-1477	OV	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	0.6667
p.G438S	TCGA-A5-A2K7	UCEC	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	0.2778
p.A440T	TCGA-AA-3811	COAD	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	0.6028
p.G446R	TCGA-AP-A051	UCEC	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	0.6457
p.A433T	TCGA-CV-6953	HNSC	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	0.1389
p.A433V	TCGA-EE-A2MD	SKCM	TCGA	ARAGLNGLQ	DEG_APCC_DBOX_1	0.1389
p.S456N	SIDM00386	Ewing's Sarcoma	GDSC	ARAGLNGLQ	DEG_APCC_DBOX_1	0.1111
p.S456N	SIDM00482	Chronic Myelogenous Leukemia	GDSC	ARAGLNGLQ	DEG_APCC_DBOX_1	0.1111
p.S456N	SIDM00056	Thyroid Gland Carcinoma	GDSC	ARAGLNGLQ	DEG_APCC_DBOX_1	0.1111
p.R458S	SIDM00261	Ewing's Sarcoma	GDSC	ARAGLNGLQ	DEG_APCC_DBOX_1	0.0556
p.R458S	ACH-002109	Bone Cancer	CCLE	ARAGLNGLQ	DEG_APCC_DBOX_1	0.0556
p.R458S	ES8	bone	COSMIC	ARAGLNGLQ	DEG_APCC_DBOX_1	0.0556
p.R433S	ES8	bone	COSMIC	ARAGLNGLQ	DEG_APCC_DBOX_1	0.1389
p.E458G	ONS-76	central_nervous_system	COSMIC	ARAGLNGLQ	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96S55	ATPase WRNIP1	DEG_APCC_DBOX_1	440:448	ARAGLNGLQ	APC,CDC20,FZR1	0.6859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons