DegronMD - Q86Z20(CCDC125)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S9R	TCGA-75-6212	LUAD	TCGA	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.7427
p.S9R	DO25777	LUAD	ICGC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.7427
p.N446H	TCGA-AP-A0LM	UCEC	TCGA	IKENF	DEG_APCC_KENBOX_2	448:452	Mutation rewiring degron network	0.2778
p.P447H	TCGA-AZ-6598	COAD	TCGA	IKENF	DEG_APCC_KENBOX_2	448:452	Mutation rewiring degron network	0.3056
p.S2N	TCGA-CN-5370	HNSC	TCGA	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.25
p.S2N	DO15126	HNSC	ICGC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.25
p.R459H	TCGA-EO-A22X	UCEC	TCGA	IKENF	DEG_APCC_KENBOX_2	448:452	Mutation rewiring degron network	0.1389
p.V13M	DO230346	COCA	ICGC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.V13M	DO229003	COCA	ICGC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.V13M	DO229005	COCA	ICGC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.V13M	DO229346	LAML	ICGC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.V13M	DO230659	LAML	ICGC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.V13M	DO231140	LAML	ICGC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.V13M	DO230993	LUSC	ICGC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.V13M	DO231049	LUSC	ICGC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.E17K	DO224769	COCA	ICGC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.1111
p.N456D	SIDM01045	Endometrial Carcinoma	GDSC	IKENF	DEG_APCC_KENBOX_2	448:452	Mutation rewiring degron network	0.2222
p.N456D	ACH-000978	Endometrial/Uterine Cancer	CCLE	IKENF	DEG_APCC_KENBOX_2	448:452	Mutation rewiring degron network	0.2222
p.N456D	EN	endometrium	COSMIC	IKENF	DEG_APCC_KENBOX_2	448:452	Mutation rewiring degron network	0.2222
p.S8L	ACH-001853	Bile Duct Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.7667
p.E17G	AGS	stomach	COSMIC	ARSSS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.1111

Kaplan plot for CCDC125 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC125

UniProt ID: Q86Z20

Entrez ID: 202243

Protein name: Coiled-coil domain-containing protein 125 (Protein kenae)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC125 in