DegronMD

Uniprot ID: Q86Z20

Source protein: Coiled-coil domain-containing protein 125

Source gene: CCDC125

Class: DEG_APCC_KENBOX_2

Location: 448:452

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9223

ASA_SCORE: 104.7

COIL: 0.8058

CONS_SCORE: 0.2263

DSS_SCORE: 0.5405

HELIX: 0.1626

FCONS_SCORE: 0.9

RIG_SCORE: 0.7474

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N446H	TCGA-AP-A0LM	UCEC	TCGA	IKENF	DEG_APCC_KENBOX_2	0.2778
p.P447H	TCGA-AZ-6598	COAD	TCGA	IKENF	DEG_APCC_KENBOX_2	0.3056
p.R459H	TCGA-EO-A22X	UCEC	TCGA	IKENF	DEG_APCC_KENBOX_2	0.1389
p.N456D	SIDM01045	Endometrial Carcinoma	GDSC	IKENF	DEG_APCC_KENBOX_2	0.2222
p.N456D	ACH-000978	Endometrial/Uterine Cancer	CCLE	IKENF	DEG_APCC_KENBOX_2	0.2222
p.N456D	EN	endometrium	COSMIC	IKENF	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86Z20	Coiled-coil domain-containing protein 125	DEG_APCC_KENBOX_2	448:452	IKENF	APC,CDC20,FZR1	0.9223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons