DegronMD - Q8NCE2(MTMR14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V559A	TCGA-AP-A1DV	UCEC	TCGA	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0833
p.V559A	DO43186	UCEC	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0833
p.R568W	TCGA-BS-A0VI	UCEC	TCGA	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.8634
p.R568W	DO41764	UCEC	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.8634
p.D583N	TCGA-EE-A2M6	SKCM	TCGA	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0833
p.D583N	DO222514	MELA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0833
p.D583N	DO37976	SKCM	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0833
p.R500C	TCGA-EY-A215	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.0556
p.R500C	DO42665	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.0556
p.R568Q	TCGA-LN-A7HY	ESCA	TCGA	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.7329
p.R568Q	SIDM00373	Endometrial Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.7329
p.R568Q	ACH-000974	Endometrial/Uterine Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.7329
p.E567K	TCGA-XF-A8HE	BLCA	TCGA	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.3056
p.E567K	DO49797	BLCA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.3056
p.H520L	DO48448	BLCA	ICGC	ARSSS	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.1667
p.V570F	DO229028	LICA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.5957
p.S580I	DO229026	LICA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation blocking phosphorylation signal	0.6111
p.G563V	DO229045	LICA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1944
p.H572R	DO46847	RECA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.8244
p.M558L	SIDM00845	Burkitt's Lymphoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0556
p.M558L	SIDM00461	Acute Myeloid Leukemia	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0556
p.M558L	SIDM01519	Head and Neck Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0556
p.M558L	ACH-000786	Lymphoma	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0556
p.M558L	ACH-000992	Head and Neck Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0556
p.M558L	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0556
p.M558L	Daudi	haematopoietic and lymphoid tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.0556
p.T560S	SIDM00845	Burkitt's Lymphoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.T560S	SIDM01519	Head and Neck Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.T560S	ACH-000786	Lymphoma	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.T560S	ACH-000992	Head and Neck Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.T560S	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.T560S	Daudi	haematopoietic and lymphoid tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.E567D	SIDM00845	Burkitt's Lymphoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.3056
p.E567D	SIDM01519	Head and Neck Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.3056
p.E567D	ACH-000786	Lymphoma	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.3056
p.E567D	ACH-000992	Head and Neck Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.3056
p.E567D	Daudi	haematopoietic and lymphoid tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.3056
p.A569P	SIDM00845	Burkitt's Lymphoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.6392
p.A569P	SIDM00461	Acute Myeloid Leukemia	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.6392
p.A569P	SIDM01519	Head and Neck Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.6392
p.A569P	ACH-000786	Lymphoma	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.6392
p.A569P	ACH-000992	Head and Neck Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.6392
p.A569P	Daudi	haematopoietic and lymphoid tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation altering degron motif	0.6392
p.P582Q	SIDM00845	Burkitt's Lymphoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.P582Q	SIDM00461	Acute Myeloid Leukemia	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.P582Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.P582Q	SIDM01519	Head and Neck Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.P582Q	ACH-000786	Lymphoma	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.P582Q	ACH-000992	Head and Neck Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.P582Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.T560M	SIDM00217	Colorectal Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.T560M	ACH-000999	Colon/Colorectal Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.T560M	SNU-1040	large intestine	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation rewiring degron network	0.1111
p.R500H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	ARSSS	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.0556
p.R500H	ACH-000937	Leukemia	CCLE	ARSSS	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.0556
p.R500H	PF-382	haematopoietic and lymphoid tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.0556
p.A576D	RH-1	soft tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	568:574	Mutation blocking phosphorylation signal	0.7222
p.A516D	RH-1	soft tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	510:514	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTMR14

UniProt ID: Q8NCE2

Entrez ID: 64419

Protein name: Myotubularin-related protein 14 (EC 3.1.3.-) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (hJumpy)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTMR14 in