DegronMD

Uniprot ID: Q8NCE2

Source protein: Myotubularin-related protein 14

Source gene: MTMR14

Class: LIG_APCC_ABBAyCdc20_2

Location: 568:574

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8797

ASA_SCORE: 84.4143

COIL: 0.6787

CONS_SCORE: 0.429

DSS_SCORE: 0.3264

HELIX: 0.161

FCONS_SCORE: 0.9369

RIG_SCORE: 0.7935

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V559A	TCGA-AP-A1DV	UCEC	TCGA	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V559A	DO43186	UCEC	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R568W	TCGA-BS-A0VI	UCEC	TCGA	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.8634
p.R568W	DO41764	UCEC	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.8634
p.D583N	TCGA-EE-A2M6	SKCM	TCGA	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D583N	DO222514	MELA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D583N	DO37976	SKCM	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R568Q	TCGA-LN-A7HY	ESCA	TCGA	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R568Q	SIDM00373	Endometrial Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R568Q	ACH-000974	Endometrial/Uterine Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.7329
p.E567K	TCGA-XF-A8HE	BLCA	TCGA	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E567K	DO49797	BLCA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.V570F	DO229028	LICA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.5957
p.S580I	DO229026	LICA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.6111
p.G563V	DO229045	LICA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.H572R	DO46847	RECA	ICGC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.8244
p.M558L	SIDM00845	Burkitt's Lymphoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.M558L	SIDM00461	Acute Myeloid Leukemia	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.M558L	SIDM01519	Head and Neck Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.M558L	ACH-000786	Lymphoma	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.M558L	ACH-000992	Head and Neck Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.M558L	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.M558L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.T560S	SIDM00845	Burkitt's Lymphoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T560S	SIDM01519	Head and Neck Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T560S	ACH-000786	Lymphoma	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T560S	ACH-000992	Head and Neck Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T560S	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T560S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E567D	SIDM00845	Burkitt's Lymphoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E567D	SIDM01519	Head and Neck Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E567D	ACH-000786	Lymphoma	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E567D	ACH-000992	Head and Neck Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E567D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A569P	SIDM00845	Burkitt's Lymphoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.6392
p.A569P	SIDM00461	Acute Myeloid Leukemia	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.6392
p.A569P	SIDM01519	Head and Neck Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.6392
p.A569P	ACH-000786	Lymphoma	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.6392
p.A569P	ACH-000992	Head and Neck Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.6392
p.A569P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.6392
p.P582Q	SIDM00845	Burkitt's Lymphoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P582Q	SIDM00461	Acute Myeloid Leukemia	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P582Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P582Q	SIDM01519	Head and Neck Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P582Q	ACH-000786	Lymphoma	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P582Q	ACH-000992	Head and Neck Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P582Q	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T560M	SIDM00217	Colorectal Carcinoma	GDSC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T560M	ACH-000999	Colon/Colorectal Cancer	CCLE	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T560M	SNU-1040	large_intestine	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A576D	RH-1	soft_tissue	COSMIC	RAVLHTD	LIG_APCC_ABBAyCdc20_2	0.7222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RAVLHTD

Degron related mutations and impact score

Drug responses associated with MTMR14 mutations

All proteins holding degron of RAVLHTD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCE2	Myotubularin-related protein 14	LIG_APCC_ABBAyCdc20_2	568:574	RAVLHTD	APC,CDC20,FZR1	0.8797	More...