DegronMD - Q9Y6R9(CCDC61)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L272P	TCGA-DD-A116	LIHC	TCGA	LRARLKTLT	DEG_APCC_DBOX_1	265:273	Mutation altering degron motif	0.7582
p.R310H	DO38404	STAD	ICGC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.25
p.S318L	DO229216	THCA	ICGC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.3056
p.E319D	SIDM01090	Colorectal Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.2778
p.E319D	SIDM00846	Cervical Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.2778
p.E319D	SIDM00863	Burkitt's Lymphoma	GDSC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.2778
p.A313E	SIDM00491	Thyroid Gland Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7701
p.A313E	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7701
p.A313E	SIDM00279	Gastric Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7701
p.G326D	SIDM00333	Endometrial Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0833
p.G326D	ACH-000988	Endometrial/Uterine Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0833
p.R314S	SIDM00254	Neuroblastoma	GDSC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.6316
p.R314S	SIDM00844	Burkitt's Lymphoma	GDSC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.6316
p.R314S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.6316
p.R314S	SIDM00808	Burkitt's Lymphoma	GDSC	ARSSS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.6316
p.R266C	SIDM01577	Plasma Cell Myeloma	GDSC	LRARLKTLT	DEG_APCC_DBOX_1	265:273	Mutation altering degron motif	0.8301
p.R266C	SIDM01433	Kidney Carcinoma	GDSC	LRARLKTLT	DEG_APCC_DBOX_1	265:273	Mutation altering degron motif	0.8301
p.R260H	Hs940-T	skin	COSMIC	LRARLKTLT	DEG_APCC_DBOX_1	265:273	Mutation rewiring degron network	0.1944
p.P279A	SW1710	urinary tract	COSMIC	LRARLKTLT	DEG_APCC_DBOX_1	265:273	Mutation rewiring degron network	0.1667

Kaplan plot for CCDC61 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC61

UniProt ID: Q9Y6R9

Entrez ID: 729440

Protein name: Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC61 in