DegronMD

Uniprot ID: Q9Y6R9

Source protein: Centrosomal protein CCDC61

Source gene: CCDC61

Class: DEG_APCC_DBOX_1

Location: 265:273

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5525

ASA_SCORE: 93.8667

COIL: 0.163

CONS_SCORE: 0.5381

DSS_SCORE: 0.4627

HELIX: 0.8418

FCONS_SCORE: 1.1287

RIG_SCORE: 0.749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L272P	TCGA-DD-A116	LIHC	TCGA	LRARLKTLT	DEG_APCC_DBOX_1	0.7582
p.R266C	SIDM01577	Plasma Cell Myeloma	GDSC	LRARLKTLT	DEG_APCC_DBOX_1	0.8301
p.R266C	SIDM01433	Kidney Carcinoma	GDSC	LRARLKTLT	DEG_APCC_DBOX_1	0.8301
p.R260H	Hs940-T	skin	COSMIC	LRARLKTLT	DEG_APCC_DBOX_1	0.1944
p.P279A	SW1710	urinary_tract	COSMIC	LRARLKTLT	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6R9	Centrosomal protein CCDC61	DEG_APCC_DBOX_1	265:273	LRARLKTLT	APC,CDC20,FZR1	0.5525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons