DegronMD

Uniprot ID: Q9NP85

Source protein: Podocin

Source gene: NPHS2

Class: DEG_SPOP_SBC_1

Location: 5:9

E3 ligase: SPOP

DEGRON score: 0.843

ASA_SCORE: 103.06

COIL: 0.9116

CONS_SCORE: 0.27

DSS_SCORE: 0.9128

HELIX: 0.0926

FCONS_SCORE: 1.0538

RIG_SCORE: 0.5986

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A5V	TCGA-CM-5861	COAD	TCGA	ARSSS	DEG_SPOP_SBC_1	0.5825
p.A5V	DO7918	COAD	ICGC	ARSSS	DEG_SPOP_SBC_1	0.5825
p.R15Q	DO477	BLCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1667
p.R6Q	DO219873	SKCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.6218
p.R10T	SIDM01175	Other Sarcomas	GDSC	ARSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NL88	Protein shisa-7	DEG_SPOP_SBC_1	243:247	ARSSS	SPOP	0.8952	More...
O43918	Autoimmune regulator	DEG_SPOP_SBC_1	246:250	ARSSS	SPOP	0.8679	More...
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_SPOP_SBC_1	395:399	ARSSS	SPOP	0.9781	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	533:537	ARSSS	SPOP	0.6596	More...
P08047	Transcription factor Sp1	DEG_SPOP_SBC_1	38:42	ARSSS	SPOP	0.9685	More...
P0C1S8	Wee1-like protein kinase 2	DEG_SPOP_SBC_1	553:557	ARSSS	SPOP	0.9215	More...
P10109	Adrenodoxin, mitochondrial	DEG_SPOP_SBC_1	59:63	ARSSS	SPOP	0.9801	More...
P41594	Metabotropic glutamate receptor 5	DEG_SPOP_SBC_1	1048:1052	ARSSS	SPOP	0.9696	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	994:998	ARSSS	SPOP	0.9945	More...
Q14721	Potassium voltage-gated channel subfamily B member 1	DEG_SPOP_SBC_1	515:519	ARSSS	SPOP	0.707	More...
Q5VWQ8	Disabled homolog 2-interacting protein	DEG_SPOP_SBC_1	724:728	ARSSS	SPOP	0.8774	More...
Q7Z591	Microtubule organization protein AKNA	DEG_SPOP_SBC_1	1157:1161	ARSSS	SPOP	0.9961	More...
Q86YJ5	E3 ubiquitin-protein ligase MARCHF9	DEG_SPOP_SBC_1	329:333	ARSSS	SPOP	0.8149	More...
Q86Z20	Coiled-coil domain-containing protein 125	DEG_SPOP_SBC_1	5:9	ARSSS	SPOP	0.7355	More...
Q8NCE2	Myotubularin-related protein 14	DEG_SPOP_SBC_1	510:514	ARSSS	SPOP	0.7067	More...
Q96AY4	Tetratricopeptide repeat protein 28	DEG_SPOP_SBC_1	2237:2241	ARSSS	SPOP	0.9436	More...
Q96S55	ATPase WRNIP1	DEG_SPOP_SBC_1	129:133	ARSSS	SPOP	0.9833	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	502:506	ARSSS	SPOP	0.9877	More...
Q9H773	dCTP pyrophosphatase 1	DEG_SPOP_SBC_1	134:138	ARSSS	SPOP	0.8753	More...
Q9NP85	Podocin	DEG_SPOP_SBC_1	5:9	ARSSS	SPOP	0.843	More...
Q9P246	Stromal interaction molecule 2	DEG_SPOP_SBC_1	507:511	ARSSS	SPOP	0.9992	More...
Q9UPN4	Centrosomal protein of 131 kDa	DEG_SPOP_SBC_1	142:146	ARSSS	SPOP	0.9791	More...
Q9Y6R9	Centrosomal protein CCDC61	DEG_SPOP_SBC_1	313:317	ARSSS	SPOP	0.8882	More...
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_SPOP_SBC_1	287:291	ARSSS	SPOP	0.9364	More...
Q92610	Zinc finger protein 592	DEG_SPOP_SBC_1	953:957	ARSSS	SPOP	0.8742	More...
A6NNA2	Serine/arginine repetitive matrix protein 3	DEG_SPOP_SBC_1	426:430	ARSSS	SPOP	0.73	More...
B2RC85	Radial spoke head 10 homolog B2	DEG_SPOP_SBC_1	693:697	ARSSS	SPOP	0.9652	More...
E7EW31	Proline-rich basic protein 1	DEG_SPOP_SBC_1	782:786	ARSSS	SPOP	0.9376	More...
P0C881	Radial spoke head 10 homolog B	DEG_SPOP_SBC_1	693:697	ARSSS	SPOP	0.9698	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	475:479	ARSSS	SPOP	0.6316	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSSS

Degron related mutations and impact score

Drug responses associated with NPHS2 mutations

All proteins holding degron of ARSSS