DegronMD

Uniprot ID: O43918

Source protein: Autoimmune regulator

Source gene: AIRE

Class: DEG_SPOP_SBC_1

Location: 246:250

E3 ligase: SPOP

DEGRON score: 0.8679

ASA_SCORE: 85.72

COIL: 0.8402

CONS_SCORE: 0.4975

DSS_SCORE: 0.667

HELIX: 0.08

FCONS_SCORE: 1.1438

RIG_SCORE: 0.5772

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E237K	TCGA-AZ-4315	COAD	TCGA	ARSSS	DEG_SPOP_SBC_1	0.0833
p.E237K	TCGA-BS-A0UV	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.0833
p.E237K	TCGA-DD-A3A9	LIHC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.0833
p.E237K	TCGA-JW-A5VL	CESC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.0833
p.E237K	DO49976	CESC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.0833
p.E237K	DO8842	COAD	ICGC	ARSSS	DEG_SPOP_SBC_1	0.0833
p.E237K	DO44888	LIHC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.0833
p.E237K	DO42793	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.0833
p.E237K	SIDM00225	Melanoma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.0833
p.E237K	ACH-002143	Skin Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	0.0833
p.E237K	IST-MEL1	skin	COSMIC	ARSSS	DEG_SPOP_SBC_1	0.0833
p.G255D	DO233197	GACA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1944
p.R249C	DO228585	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.8301
p.G260R	DO228520	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.0556
p.G260R	DO42312	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.0556
p.V256F	DO229019	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1667
p.A244T	DO228138	PBCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.2778
p.R238W	DO232761	PBCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1111
p.P253S	DO48665	SKCM	ICGC	ARSSS	DEG_SPOP_SBC_1	0.3611
p.R238L	DO47623	SKCM	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1111
p.R249H	DO48016	STAD	ICGC	ARSSS	DEG_SPOP_SBC_1	0.8244
p.A243T	DO47767	STAD	ICGC	ARSSS	DEG_SPOP_SBC_1	0.3611
p.F246S	DO229264	THCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.7982
p.S241I	DO229213	THCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1944
p.P254S	DO229242	THCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.2222
p.P252L	SIDM00773	Non-Cancerous	GDSC	ARSSS	DEG_SPOP_SBC_1	0.2778
p.P252L	SIDM00878	Breast Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.2778
p.P252L	SIDM00954	Breast Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.2778
p.P252L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	ARSSS	DEG_SPOP_SBC_1	0.2778
p.P252L	SIDM00774	Breast Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.2778
p.P252L	SIDM01318	Hepatocellular Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.2778
p.L255P	SIDM01220	Glioma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.1944
p.L255P	ACH-000760	Brain Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	0.1944
p.L255P	ACH-002269	Brain Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	0.1944
p.L255P	LNZTA3WT4	central_nervous_system	COSMIC	ARSSS	DEG_SPOP_SBC_1	0.1944
p.R247H	SIDM01617	Endometrial Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.7133
p.S250C	ACH-001433	Sarcoma	CCLE	ARSSS	DEG_SPOP_SBC_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NL88	Protein shisa-7	DEG_SPOP_SBC_1	243:247	ARSSS	SPOP	0.8952	More...
O43918	Autoimmune regulator	DEG_SPOP_SBC_1	246:250	ARSSS	SPOP	0.8679	More...
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_SPOP_SBC_1	395:399	ARSSS	SPOP	0.9781	More...
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	533:537	ARSSS	SPOP	0.6596	More...
P08047	Transcription factor Sp1	DEG_SPOP_SBC_1	38:42	ARSSS	SPOP	0.9685	More...
P0C1S8	Wee1-like protein kinase 2	DEG_SPOP_SBC_1	553:557	ARSSS	SPOP	0.9215	More...
P10109	Adrenodoxin, mitochondrial	DEG_SPOP_SBC_1	59:63	ARSSS	SPOP	0.9801	More...
P41594	Metabotropic glutamate receptor 5	DEG_SPOP_SBC_1	1048:1052	ARSSS	SPOP	0.9696	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	994:998	ARSSS	SPOP	0.9945	More...
Q14721	Potassium voltage-gated channel subfamily B member 1	DEG_SPOP_SBC_1	515:519	ARSSS	SPOP	0.707	More...
Q5VWQ8	Disabled homolog 2-interacting protein	DEG_SPOP_SBC_1	724:728	ARSSS	SPOP	0.8774	More...
Q7Z591	Microtubule organization protein AKNA	DEG_SPOP_SBC_1	1157:1161	ARSSS	SPOP	0.9961	More...
Q86YJ5	E3 ubiquitin-protein ligase MARCHF9	DEG_SPOP_SBC_1	329:333	ARSSS	SPOP	0.8149	More...
Q86Z20	Coiled-coil domain-containing protein 125	DEG_SPOP_SBC_1	5:9	ARSSS	SPOP	0.7355	More...
Q8NCE2	Myotubularin-related protein 14	DEG_SPOP_SBC_1	510:514	ARSSS	SPOP	0.7067	More...
Q96AY4	Tetratricopeptide repeat protein 28	DEG_SPOP_SBC_1	2237:2241	ARSSS	SPOP	0.9436	More...
Q96S55	ATPase WRNIP1	DEG_SPOP_SBC_1	129:133	ARSSS	SPOP	0.9833	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	502:506	ARSSS	SPOP	0.9877	More...
Q9H773	dCTP pyrophosphatase 1	DEG_SPOP_SBC_1	134:138	ARSSS	SPOP	0.8753	More...
Q9NP85	Podocin	DEG_SPOP_SBC_1	5:9	ARSSS	SPOP	0.843	More...
Q9P246	Stromal interaction molecule 2	DEG_SPOP_SBC_1	507:511	ARSSS	SPOP	0.9992	More...
Q9UPN4	Centrosomal protein of 131 kDa	DEG_SPOP_SBC_1	142:146	ARSSS	SPOP	0.9791	More...
Q9Y6R9	Centrosomal protein CCDC61	DEG_SPOP_SBC_1	313:317	ARSSS	SPOP	0.8882	More...
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_SPOP_SBC_1	287:291	ARSSS	SPOP	0.9364	More...
Q92610	Zinc finger protein 592	DEG_SPOP_SBC_1	953:957	ARSSS	SPOP	0.8742	More...
A6NNA2	Serine/arginine repetitive matrix protein 3	DEG_SPOP_SBC_1	426:430	ARSSS	SPOP	0.73	More...
B2RC85	Radial spoke head 10 homolog B2	DEG_SPOP_SBC_1	693:697	ARSSS	SPOP	0.9652	More...
E7EW31	Proline-rich basic protein 1	DEG_SPOP_SBC_1	782:786	ARSSS	SPOP	0.9376	More...
P0C881	Radial spoke head 10 homolog B	DEG_SPOP_SBC_1	693:697	ARSSS	SPOP	0.9698	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	475:479	ARSSS	SPOP	0.6316	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSSS

Degron related mutations and impact score

Drug responses associated with AIRE mutations

All proteins holding degron of ARSSS