DegronMD - Q9UPN4(CEP131)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D548N	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSQQEGWVPEA	DEG_COP1_1	548:558	Mutation altering degron motif	0.6932
p.D548N	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	DSQQEGWVPEA	DEG_COP1_1	548:558	Mutation altering degron motif	0.6932
p.R143W	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7523
p.R143W	SIDM01664	Prostate Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7523
p.L392F	SIDM00007	Other Solid Cancers	GDSC	LSPTPGGT	DEG_SCF_FBW7_1	380:387	Mutation rewiring degron network	0.1944
p.L392F	MCC13	skin	COSMIC	LSPTPGGT	DEG_SCF_FBW7_1	380:387	Mutation rewiring degron network	0.1944
p.H462L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SRGPLEELL	DEG_APCC_DBOX_1	453:461	Mutation rewiring degron network	0.3056
p.H462L	H513	pleura	COSMIC	SRGPLEELL	DEG_APCC_DBOX_1	453:461	Mutation rewiring degron network	0.3056
p.P446S	SIDM01003	T-Lymphoblastic Leukemia	GDSC	SRGPLEELL	DEG_APCC_DBOX_1	453:461	Mutation rewiring degron network	0.1389
p.P446S	SIDM01706	Hodgkin's Lymphoma	GDSC	SRGPLEELL	DEG_APCC_DBOX_1	453:461	Mutation rewiring degron network	0.1389
p.P446S	SIDM01518	Oral Cavity Carcinoma	GDSC	SRGPLEELL	DEG_APCC_DBOX_1	453:461	Mutation rewiring degron network	0.1389
p.S144N	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.818
p.S144N	KYSE-70	oesophagus	COSMIC	ARSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.818
p.P471S	SIDM01228	Melanoma	GDSC	SRGPLEELL	DEG_APCC_DBOX_1	453:461	Mutation rewiring degron network	0.0556
p.P471S	CHL-1	skin	COSMIC	SRGPLEELL	DEG_APCC_DBOX_1	453:461	Mutation rewiring degron network	0.0556
p.V370A	SIDM00490	Glioma	GDSC	LSPTPGGT	DEG_SCF_FBW7_1	380:387	Mutation rewiring degron network	0.0556
p.V370A	Becker	central nervous system	COSMIC	LSPTPGGT	DEG_SCF_FBW7_1	380:387	Mutation rewiring degron network	0.0556
p.K541N	SIDM01322	Oral Cavity Carcinoma	GDSC	DSQQEGWVPEA	DEG_COP1_1	548:558	Mutation substituting flanking lysine	0.25
p.A788V	SIDM01608	Endometrial Carcinoma	GDSC	RQRLYSE	LIG_APCC_ABBAyCdc20_2	793:799	Mutation rewiring degron network	0.1944
p.A801D	SIDM01750	Melanoma	GDSC	RQRLYSE	LIG_APCC_ABBAyCdc20_2	793:799	Mutation rewiring degron network	0.2778
p.E783K	Becker	central nervous system	COSMIC	RQRLYSE	LIG_APCC_ABBAyCdc20_2	793:799	Mutation rewiring degron network	0.0556
p.D545N	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	DSQQEGWVPEA	DEG_COP1_1	548:558	Mutation rewiring degron network	0.25
p.S793N	Becker	central nervous system	COSMIC	RQRLYSE	LIG_APCC_ABBAyCdc20_2	793:799	Mutation altering degron motif	0.7069
p.S790N	Becker	central nervous system	COSMIC	RQRLYSE	LIG_APCC_ABBAyCdc20_2	793:799	Mutation rewiring degron network	0.25

Kaplan plot for CEP131 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP131

UniProt ID: Q9UPN4

Entrez ID: 22994

Protein name: Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP131 in