DegronMD

Uniprot ID: Q9UPN4

Source protein: Centrosomal protein of 131 kDa

Source gene: CEP131

Class: DEG_APCC_DBOX_1

Location: 453:461

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9927

ASA_SCORE: 78.9111

COIL: 0.3408

CONS_SCORE: 0.4446

DSS_SCORE: 0.5372

HELIX: 0.6444

FCONS_SCORE: 1.0133

RIG_SCORE: 0.6552

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H462L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SRGPLEELL	DEG_APCC_DBOX_1	0.3056
p.H462L	H513	pleura	COSMIC	SRGPLEELL	DEG_APCC_DBOX_1	0.3056
p.P446S	SIDM01003	T-Lymphoblastic Leukemia	GDSC	SRGPLEELL	DEG_APCC_DBOX_1	0.1389
p.P446S	SIDM01706	Hodgkin's Lymphoma	GDSC	SRGPLEELL	DEG_APCC_DBOX_1	0.1389
p.P446S	SIDM01518	Oral Cavity Carcinoma	GDSC	SRGPLEELL	DEG_APCC_DBOX_1	0.1389
p.P471S	SIDM01228	Melanoma	GDSC	SRGPLEELL	DEG_APCC_DBOX_1	0.0556
p.P471S	CHL-1	skin	COSMIC	SRGPLEELL	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN4	Centrosomal protein of 131 kDa	DEG_APCC_DBOX_1	453:461	SRGPLEELL	APC,CDC20,FZR1	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons