DegronMD

Uniprot ID: Q9UPN4

Source protein: Centrosomal protein of 131 kDa

Source gene: CEP131

Class: DEG_SCF_FBW7_1

Location: 380:387

E3 ligase: FBXW7

DEGRON score: 0.8409

ASA_SCORE: 76.525

COIL: 0.901

CONS_SCORE: 0.3709

DSS_SCORE: 0.8015

HELIX: 0.0846

FCONS_SCORE: 0.9404

RIG_SCORE: 0.5554

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L392F	SIDM00007	Other Solid Cancers	GDSC	LSPTPGGT	DEG_SCF_FBW7_1	0.1944
p.L392F	MCC13	skin	COSMIC	LSPTPGGT	DEG_SCF_FBW7_1	0.1944
p.V370A	SIDM00490	Glioma	GDSC	LSPTPGGT	DEG_SCF_FBW7_1	0.0556
p.V370A	Becker	central_nervous_system	COSMIC	LSPTPGGT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN4	Centrosomal protein of 131 kDa	DEG_SCF_FBW7_1	380:387	LSPTPGGT	FBXW7	0.8409	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons