DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RQRLYSE
Uniprot ID:
Q9UPN4
Source protein:
Centrosomal protein of 131 kDa
Source gene:
CEP131
Class:
LIG_APCC_ABBAyCdc20_2
Location:
793:799
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7197
ASA_SCORE:
109.9429
COIL:
0.0709
CONS_SCORE:
0.6002
DSS_SCORE:
0.3465
HELIX:
0.9294
FCONS_SCORE:
1.1448
RIG_SCORE:
0.7388
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A788V
SIDM01608
Endometrial Carcinoma
GDSC
RQRLYSE
LIG_APCC_ABBAyCdc20_2
0.1944
p.A801D
SIDM01750
Melanoma
GDSC
RQRLYSE
LIG_APCC_ABBAyCdc20_2
0.2778
p.E783K
Becker
central_nervous_system
COSMIC
RQRLYSE
LIG_APCC_ABBAyCdc20_2
0.0556
p.S793N
Becker
central_nervous_system
COSMIC
RQRLYSE
LIG_APCC_ABBAyCdc20_2
0.7069
p.S790N
Becker
central_nervous_system
COSMIC
RQRLYSE
LIG_APCC_ABBAyCdc20_2
0.25
Drug responses associated with CEP131 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RQRLYSE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UPN4
Centrosomal protein of 131 kDa
LIG_APCC_ABBAyCdc20_2
793:799
RQRLYSE
APC,CDC20,FZR1
0.7197
More...