DegronMD

Uniprot ID: Q9UPN4

Source protein: Centrosomal protein of 131 kDa

Source gene: CEP131

Class: DEG_COP1_1

Location: 548:558

E3 ligase: COP1

DEGRON score: 0.7417

ASA_SCORE: 101.6091

COIL: 0.772

CONS_SCORE: 0.3829

DSS_SCORE: 0.6893

HELIX: 0.1993

FCONS_SCORE: 0.8426

RIG_SCORE: 0.6737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D548N	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSQQEGWVPEA	DEG_COP1_1	0.6932
p.D548N	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSQQEGWVPEA	DEG_COP1_1	0.6932
p.K541N	SIDM01322	Oral Cavity Carcinoma	GDSC	DSQQEGWVPEA	DEG_COP1_1	0.25
p.D545N	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSQQEGWVPEA	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN4	Centrosomal protein of 131 kDa	DEG_COP1_1	548:558	DSQQEGWVPEA	COP1	0.7417	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons