DegronMD - A6NNA2(SRRM3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A19T	TCGA-06-A5U1	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1667
p.A19T	DO50111	GBM	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1667
p.P117Q	TCGA-A4-7583	KIRP	TCGA	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.7035
p.P117Q	TCGA-D3-A2J6	SKCM	TCGA	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.7035
p.P117Q	DO20870	KIRP	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.7035
p.P117Q	DO37901	SKCM	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.7035
p.G109V	TCGA-EE-A2MG	SKCM	TCGA	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.2222
p.G109V	DO37421	SKCM	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.2222
p.R104M	TCGA-ER-A19Q	SKCM	TCGA	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.0833
p.R104M	DO47497	SKCM	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.0833
p.G126D	TCGA-EY-A1GU	UCEC	TCGA	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1667
p.G126D	DO41518	UCEC	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1667
p.T116I	TCGA-QC-A7B5	SARC	TCGA	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.8189
p.T116I	DO220239	SARC	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.8189
p.E105Q	DO224852	BRCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1111
p.E105Q	DO52550	BRCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1111
p.R107W	DO222874	COCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1667
p.R107W	SIDM01617	Endometrial Carcinoma	GDSC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1667
p.R107W	ACH-000994	Endometrial/Uterine Cancer	CCLE	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1667
p.A123T	DO52450	COCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.25
p.S27A	DO229010	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation altering degron motif	0.87
p.S27A	DO229013	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation altering degron motif	0.87
p.S27A	DO229016	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation altering degron motif	0.87
p.S27A	DO229005	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation altering degron motif	0.87
p.S27A	DO229216	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation altering degron motif	0.87
p.R118Q	DO234332	ESAD	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.6218
p.V113L	DO228978	LICA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.5654
p.V113L	DO229024	LICA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.5654
p.P125Q	DO50724	ORCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1944
p.P117T	DO229275	THCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.7031
p.P33T	DO229213	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.2222
p.G21S	SIDM01307	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.2222
p.A130T	SIDM00683	Prostate Carcinoma	GDSC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.0556
p.A130T	ACH-000977	lymph node	CCLE	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.0556
p.A130T	LNCaP-Clone-FGC	prostate	COSMIC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.0556
p.L127P	SIDM00683	Prostate Carcinoma	GDSC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1389
p.L127P	ACH-000977	lymph node	CCLE	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1389
p.L127P	LNCaP-Clone-FGC	prostate	COSMIC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation rewiring degron network	0.1389
p.D17N	SIDM00600	Thyroid Gland Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1111
p.D17N	SIDM00315	Glioblastoma	GDSC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1111
p.D17N	SIDM01144	Gastric Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1111
p.D17N	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1111
p.D17N	SIDM01394	Kidney Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1111
p.D17N	SIDM01588	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	25:29	Mutation rewiring degron network	0.1111
p.A114S	SIDM00293	Small Cell Lung Carcinoma	GDSC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.6477
p.A114S	ACH-002052	Lung Cancer	CCLE	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.6477
p.A114S	LU-139	lung	COSMIC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.6477
p.A114V	SIDM00293	Small Cell Lung Carcinoma	GDSC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.5825
p.A114V	ACH-002052	Lung Cancer	CCLE	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.5825
p.A114V	LU-139	lung	COSMIC	VAETPRLT	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRRM3

UniProt ID: A6NNA2

Entrez ID:

Protein name: Serine/arginine repetitive matrix protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRRM3 in