DegronMD

Uniprot ID: A6NNA2

Source protein: Serine/arginine repetitive matrix protein 3

Source gene: SRRM3

Class: DEG_SCF_FBW7_1

Location: 113:120

E3 ligase: FBXW7

DEGRON score: 0.8374

ASA_SCORE: 79.025

COIL: 0.6941

CONS_SCORE: 0.5922

DSS_SCORE: 0.6361

HELIX: 0.2205

FCONS_SCORE: 0.953

RIG_SCORE: 0.7411

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P117Q	TCGA-A4-7583	KIRP	TCGA	VAETPRLT	DEG_SCF_FBW7_1	0.7035
p.P117Q	TCGA-D3-A2J6	SKCM	TCGA	VAETPRLT	DEG_SCF_FBW7_1	0.7035
p.P117Q	DO20870	KIRP	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.7035
p.P117Q	DO37901	SKCM	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.7035
p.G109V	TCGA-EE-A2MG	SKCM	TCGA	VAETPRLT	DEG_SCF_FBW7_1	0.2222
p.G109V	DO37421	SKCM	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.2222
p.R104M	TCGA-ER-A19Q	SKCM	TCGA	VAETPRLT	DEG_SCF_FBW7_1	0.0833
p.R104M	DO47497	SKCM	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.0833
p.G126D	TCGA-EY-A1GU	UCEC	TCGA	VAETPRLT	DEG_SCF_FBW7_1	0.1667
p.G126D	DO41518	UCEC	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.1667
p.T116I	TCGA-QC-A7B5	SARC	TCGA	VAETPRLT	DEG_SCF_FBW7_1	0.8189
p.T116I	DO220239	SARC	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.8189
p.E105Q	DO224852	BRCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.1111
p.E105Q	DO52550	BRCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.1111
p.R107W	DO222874	COCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.1667
p.R107W	SIDM01617	Endometrial Carcinoma	GDSC	VAETPRLT	DEG_SCF_FBW7_1	0.1667
p.R107W	ACH-000994	Endometrial/Uterine Cancer	CCLE	VAETPRLT	DEG_SCF_FBW7_1	0.1667
p.A123T	DO52450	COCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.25
p.R118Q	DO234332	ESAD	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.6218
p.V113L	DO228978	LICA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.5654
p.V113L	DO229024	LICA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.5654
p.P125Q	DO50724	ORCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.1944
p.P117T	DO229275	THCA	ICGC	VAETPRLT	DEG_SCF_FBW7_1	0.7031
p.A130T	SIDM00683	Prostate Carcinoma	GDSC	VAETPRLT	DEG_SCF_FBW7_1	0.0556
p.A130T	ACH-000977	lymph_node	CCLE	VAETPRLT	DEG_SCF_FBW7_1	0.0556
p.A130T	LNCaP-Clone-FGC	prostate	COSMIC	VAETPRLT	DEG_SCF_FBW7_1	0.0556
p.L127P	SIDM00683	Prostate Carcinoma	GDSC	VAETPRLT	DEG_SCF_FBW7_1	0.1389
p.L127P	ACH-000977	lymph_node	CCLE	VAETPRLT	DEG_SCF_FBW7_1	0.1389
p.L127P	LNCaP-Clone-FGC	prostate	COSMIC	VAETPRLT	DEG_SCF_FBW7_1	0.1389
p.A114S	SIDM00293	Small Cell Lung Carcinoma	GDSC	VAETPRLT	DEG_SCF_FBW7_1	0.6477
p.A114S	ACH-002052	Lung Cancer	CCLE	VAETPRLT	DEG_SCF_FBW7_1	0.6477
p.A114S	LU-139	lung	COSMIC	VAETPRLT	DEG_SCF_FBW7_1	0.6477
p.A114V	SIDM00293	Small Cell Lung Carcinoma	GDSC	VAETPRLT	DEG_SCF_FBW7_1	0.5825
p.A114V	ACH-002052	Lung Cancer	CCLE	VAETPRLT	DEG_SCF_FBW7_1	0.5825
p.A114V	LU-139	lung	COSMIC	VAETPRLT	DEG_SCF_FBW7_1	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VAETPRLT

Degron related mutations and impact score

Drug responses associated with SRRM3 mutations

All proteins holding degron of VAETPRLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NNA2	Serine/arginine repetitive matrix protein 3	DEG_SCF_FBW7_1	113:120	VAETPRLT	FBXW7	0.8374	More...