DegronMD

Uniprot ID: P0C1S8

Source protein: Wee1-like protein kinase 2

Source gene: WEE2

Class: DEG_SPOP_SBC_1

Location: 553:557

E3 ligase: SPOP

DEGRON score: 0.9215

ASA_SCORE: 59.66

COIL: 0.7038

CONS_SCORE: 0.2802

DSS_SCORE: 0.6579

HELIX: 0.0682

FCONS_SCORE: 0.9832

RIG_SCORE: 0.6162

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S556L	TCGA-Q1-A73O	CESC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.7667
p.S556L	DO51612	CESC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.7667
p.S557R	DO229259	THCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.7427
p.K551N	TCGA-AJ-A3EL	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.2778
p.K551N	DO41542	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.2778
p.T559S	SIDM00973	Melanoma	GDSC	ARSSS	DEG_SPOP_SBC_1	0.2778
p.T559S	ACH-000827	Skin Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	0.2778
p.T559S	WM793B	skin	COSMIC	ARSSS	DEG_SPOP_SBC_1	0.2778
p.G550E	TCGA-EE-A29D	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	0.25
p.G550E	DO38123	SKCM	ICGC	ARSSS	DEG_SPOP_SBC_1	0.25
p.K545N	DO225353	BRCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.2222
p.K545N	DO222884	COCA	ICGC	ARSSS	DEG_SPOP_SBC_1	0.2222
p.R563C	TCGA-A5-A0G1	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.1667
p.R563C	TCGA-IB-7651	PAAD	TCGA	ARSSS	DEG_SPOP_SBC_1	0.1667
p.R563C	DO46657	PAAD	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1667
p.R563C	DO42472	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1667
p.R563H	TCGA-D1-A15X	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.1667
p.R563H	DO43274	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1667
p.E564D	TCGA-AP-A051	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	0.1389
p.E564D	DO42673	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	0.1389

Showing 1 to 20 of 20 entries

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Drug responses associated with WEE2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ARSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94929	Actin-binding LIM protein 3	DEG_SPOP_SBC_1	533:537	ARSSS	SPOP	0.6596	More...
P10109	Adrenodoxin, mitochondrial	DEG_SPOP_SBC_1	59:63	ARSSS	SPOP	0.9801	More...
Q96S55	ATPase WRNIP1	DEG_SPOP_SBC_1	129:133	ARSSS	SPOP	0.9833	More...
O43918	Autoimmune regulator	DEG_SPOP_SBC_1	246:250	ARSSS	SPOP	0.8679	More...
Q9Y6R9	Centrosomal protein CCDC61	DEG_SPOP_SBC_1	313:317	ARSSS	SPOP	0.8882	More...
Q9UPN4	Centrosomal protein of 131 kDa	DEG_SPOP_SBC_1	142:146	ARSSS	SPOP	0.9791	More...
Q86Z20	Coiled-coil domain-containing protein 125	DEG_SPOP_SBC_1	5:9	ARSSS	SPOP	0.7355	More...
Q9H773	dCTP pyrophosphatase 1	DEG_SPOP_SBC_1	134:138	ARSSS	SPOP	0.8753	More...
Q5VWQ8	Disabled homolog 2-interacting protein	DEG_SPOP_SBC_1	724:728	ARSSS	SPOP	0.8774	More...
Q86YJ5	E3 ubiquitin-protein ligase MARCHF9	DEG_SPOP_SBC_1	329:333	ARSSS	SPOP	0.8149	More...
P41594	Metabotropic glutamate receptor 5	DEG_SPOP_SBC_1	1048:1052	ARSSS	SPOP	0.9696	More...
Q7Z591	Microtubule organization protein AKNA	DEG_SPOP_SBC_1	1157:1161	ARSSS	SPOP	0.9961	More...
Q8NCE2	Myotubularin-related protein 14	DEG_SPOP_SBC_1	510:514	ARSSS	SPOP	0.7067	More...
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_SPOP_SBC_1	287:291	ARSSS	SPOP	0.9364	More...
Q9NP85	Podocin	DEG_SPOP_SBC_1	5:9	ARSSS	SPOP	0.843	More...
Q14721	Potassium voltage-gated channel subfamily B member 1	DEG_SPOP_SBC_1	515:519	ARSSS	SPOP	0.707	More...
E7EW31	Proline-rich basic protein 1	DEG_SPOP_SBC_1	782:786	ARSSS	SPOP	0.9376	More...
A6NL88	Protein shisa-7	DEG_SPOP_SBC_1	243:247	ARSSS	SPOP	0.8952	More...
P0C881	Radial spoke head 10 homolog B	DEG_SPOP_SBC_1	693:697	ARSSS	SPOP	0.9698	More...
B2RC85	Radial spoke head 10 homolog B2	DEG_SPOP_SBC_1	693:697	ARSSS	SPOP	0.9652	More...
A6NNA2	Serine/arginine repetitive matrix protein 3	DEG_SPOP_SBC_1	426:430	ARSSS	SPOP	0.73	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	502:506	ARSSS	SPOP	0.9877	More...
Q9P246	Stromal interaction molecule 2	DEG_SPOP_SBC_1	507:511	ARSSS	SPOP	0.9992	More...
Q96AY4	Tetratricopeptide repeat protein 28	DEG_SPOP_SBC_1	2237:2241	ARSSS	SPOP	0.9436	More...
P08047	Transcription factor Sp1	DEG_SPOP_SBC_1	38:42	ARSSS	SPOP	0.9685	More...

Showing 1 to 25 of 30 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSSS

Degron related mutations and impact score

Drug responses associated with WEE2 mutations

All proteins holding degron of ARSSS