DegronMD - Q92610(ZNF592)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D233N	TCGA-21-1079	LUSC	TCGA	VEPHKD	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.2778
p.D233N	DO26846	LUSC	ICGC	VEPHKD	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.2778
p.K712T	TCGA-AG-A002	READ	TCGA	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation substituting flanking lysine	0.1667
p.E240K	TCGA-AJ-A3EL	UCEC	TCGA	VEPHKD	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.0833
p.E240K	DO41542	UCEC	ICGC	VEPHKD	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.0833
p.A953V	TCGA-BG-A0MC	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	953:957	Mutation altering degron motif	0.5825
p.A953V	DO41470	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	953:957	Mutation altering degron motif	0.5825
p.D702G	TCGA-BR-8366	STAD	TCGA	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation altering degron motif	0.7198
p.D702G	DO47791	STAD	ICGC	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation altering degron motif	0.7198
p.P943L	TCGA-D3-A8GC	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.0556
p.P943L	DO50281	SKCM	ICGC	ARSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.0556
p.P694L	TCGA-DD-AACG	LIHC	TCGA	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.25
p.P694L	DO52202	LIHC	ICGC	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.25
p.A690V	TCGA-EO-A22U	UCEC	TCGA	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.1389
p.A690V	DO43755	UCEC	ICGC	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.1389
p.P701T	TCGA-ER-A1A1	SKCM	TCGA	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation altering degron motif	0.5919
p.P701T	DO37413	SKCM	ICGC	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation altering degron motif	0.5919
p.P943S	TCGA-FR-A69P	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.0556
p.P943S	DO222843	MELA	ICGC	ARSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.0556
p.P943S	DO47292	SKCM	ICGC	ARSSS	DEG_SPOP_SBC_1	953:957	Mutation rewiring degron network	0.0556
p.R236L	DO229034	LICA	ICGC	VEPHKD	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1944
p.G239R	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	VEPHKD	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.G239R	ACH-000697	Lymphoma	CCLE	VEPHKD	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.G239R	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	VEPHKD	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.I711V	SIDM00064	Hepatocellular Carcinoma	GDSC	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.0833
p.I711V	ACH-000393	Liver Cancer	CCLE	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.0833
p.I711V	ACH-001089	Liver Cancer	CCLE	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.0833
p.I711V	HLE	liver	COSMIC	LPLYPD	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.0833
p.R954Q	SIDM00451	T-Lymphoblastic Leukemia	GDSC	ARSSS	DEG_SPOP_SBC_1	953:957	Mutation altering degron motif	0.6218
p.R954Q	ACH-000937	Leukemia	CCLE	ARSSS	DEG_SPOP_SBC_1	953:957	Mutation altering degron motif	0.6218
p.R954Q	PF-382	haematopoietic and lymphoid tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	953:957	Mutation altering degron motif	0.6218

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF592

UniProt ID: Q92610

Entrez ID: 9640

Protein name: Zinc finger protein 592

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF592 in