DegronMD

Uniprot ID: Q92610

Source protein: Zinc finger protein 592

Source gene: ZNF592

Class: LIG_APCC_ABBA_1

Location: 226:231

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.986

ASA_SCORE: 84.6667

COIL: 0.813

CONS_SCORE: 0.4673

DSS_SCORE: 0.7736

HELIX: 0.0693

FCONS_SCORE: 1.3342

RIG_SCORE: 0.6333

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D233N	TCGA-21-1079	LUSC	TCGA	VEPHKD	LIG_APCC_ABBA_1	0.2778
p.D233N	DO26846	LUSC	ICGC	VEPHKD	LIG_APCC_ABBA_1	0.2778
p.E240K	TCGA-AJ-A3EL	UCEC	TCGA	VEPHKD	LIG_APCC_ABBA_1	0.0833
p.E240K	DO41542	UCEC	ICGC	VEPHKD	LIG_APCC_ABBA_1	0.0833
p.R236L	DO229034	LICA	ICGC	VEPHKD	LIG_APCC_ABBA_1	0.1944
p.G239R	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	VEPHKD	LIG_APCC_ABBA_1	0.1111
p.G239R	ACH-000697	Lymphoma	CCLE	VEPHKD	LIG_APCC_ABBA_1	0.1111
p.G239R	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	VEPHKD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92610	Zinc finger protein 592	LIG_APCC_ABBA_1	226:231	VEPHKD	APC,CDC20,FZR1	0.986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons