DegronMD

Uniprot ID: Q92610

Source protein: Zinc finger protein 592

Source gene: ZNF592

Class: LIG_APCC_ABBA_1

Location: 697:702

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9995

ASA_SCORE: 79.5833

COIL: 0.8687

CONS_SCORE: 0.5807

DSS_SCORE: 0.3815

HELIX: 0.0187

FCONS_SCORE: 1.3736

RIG_SCORE: 0.7143

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K712T	TCGA-AG-A002	READ	TCGA	LPLYPD	LIG_APCC_ABBA_1	0.1667
p.D702G	TCGA-BR-8366	STAD	TCGA	LPLYPD	LIG_APCC_ABBA_1	0.7198
p.D702G	DO47791	STAD	ICGC	LPLYPD	LIG_APCC_ABBA_1	0.7198
p.P694L	TCGA-DD-AACG	LIHC	TCGA	LPLYPD	LIG_APCC_ABBA_1	0.25
p.P694L	DO52202	LIHC	ICGC	LPLYPD	LIG_APCC_ABBA_1	0.25
p.A690V	TCGA-EO-A22U	UCEC	TCGA	LPLYPD	LIG_APCC_ABBA_1	0.1389
p.A690V	DO43755	UCEC	ICGC	LPLYPD	LIG_APCC_ABBA_1	0.1389
p.P701T	TCGA-ER-A1A1	SKCM	TCGA	LPLYPD	LIG_APCC_ABBA_1	0.5919
p.P701T	DO37413	SKCM	ICGC	LPLYPD	LIG_APCC_ABBA_1	0.5919
p.I711V	SIDM00064	Hepatocellular Carcinoma	GDSC	LPLYPD	LIG_APCC_ABBA_1	0.0833
p.I711V	ACH-000393	Liver Cancer	CCLE	LPLYPD	LIG_APCC_ABBA_1	0.0833
p.I711V	ACH-001089	Liver Cancer	CCLE	LPLYPD	LIG_APCC_ABBA_1	0.0833
p.I711V	HLE	liver	COSMIC	LPLYPD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92610	Zinc finger protein 592	LIG_APCC_ABBA_1	697:702	LPLYPD	APC,CDC20,FZR1	0.9995	More...
Q6ZSR9	Uncharacterized protein FLJ45252	LIG_APCC_ABBA_1	6:11	LPLYPD	APC,CDC20,FZR1	0.9737	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons