DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LPLYPD
Uniprot ID:
Q6ZSR9
Source protein:
Uncharacterized protein FLJ45252
Source gene:
-
Class:
LIG_APCC_ABBA_1
Location:
6:11
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9737
ASA_SCORE:
74.2333
COIL:
0.7908
CONS_SCORE:
0.6203
DSS_SCORE:
0.7404
HELIX:
0.014
FCONS_SCORE:
1.0318
RIG_SCORE:
0.6886
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with - mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPLYPD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92610
Zinc finger protein 592
LIG_APCC_ABBA_1
697:702
LPLYPD
APC,CDC20,FZR1
0.9995
More...
Q6ZSR9
Uncharacterized protein FLJ45252
LIG_APCC_ABBA_1
6:11
LPLYPD
APC,CDC20,FZR1
0.9737
More...