DegronMD - E7EW31(PROB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G555V	TCGA-A5-A0G1	UCEC	TCGA	PGTPEPT	DEG_SCF_FBW7_1	554:560	Mutation altering degron motif	0.6421
p.G555V	DO42472	UCEC	ICGC	PGTPEPT	DEG_SCF_FBW7_1	554:560	Mutation altering degron motif	0.6421
p.L1012S	TCGA-AX-A3G9	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.0556
p.L1012S	DO41241	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.0556
p.A553T	TCGA-EY-A5W2	UCEC	TCGA	PGTPEPT	DEG_SCF_FBW7_1	554:560	Mutation rewiring degron network	0.3056
p.A553T	DO48177	UCEC	ICGC	PGTPEPT	DEG_SCF_FBW7_1	554:560	Mutation rewiring degron network	0.3056
p.P334L	TCGA-FI-A2D0	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.25
p.P334L	DO43891	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.25
p.G1010D	DO234350	ESAD	ICGC	PPSSS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.1111
p.R568P	DO233159	GACA	ICGC	PGTPEPT	DEG_SCF_FBW7_1	554:560	Mutation rewiring degron network	0.1111
p.T560I	DO228585	LICA	ICGC	PGTPEPT	DEG_SCF_FBW7_1	554:560	Mutation altering degron motif	0.7078
p.Q787R	DO229227	THCA	ICGC	ARSSS	DEG_SPOP_SBC_1	782:786	Mutation rewiring degron network	0.3056
p.A997V	SIDM00487	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.3056
p.A997V	ACH-000963	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	998:1002	Mutation rewiring degron network	0.3056
p.R783H	ACH-000468	Pancreatic Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	782:786	Mutation altering degron motif	0.7133

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons