DegronMD

Uniprot ID: E7EW31

Source protein: Proline-rich basic protein 1

Source gene: PROB1

Class: DEG_SCF_FBW7_1

Location: 554:560

E3 ligase: FBXW7

DEGRON score: 0.8292

ASA_SCORE: 89.7571

COIL: 0.9644

CONS_SCORE: 0.409

DSS_SCORE: 0.9176

HELIX: 0.0191

FCONS_SCORE: 0.9217

RIG_SCORE: 0.535

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G555V	TCGA-A5-A0G1	UCEC	TCGA	PGTPEPT	DEG_SCF_FBW7_1	0.6421
p.G555V	DO42472	UCEC	ICGC	PGTPEPT	DEG_SCF_FBW7_1	0.6421
p.A553T	TCGA-EY-A5W2	UCEC	TCGA	PGTPEPT	DEG_SCF_FBW7_1	0.3056
p.A553T	DO48177	UCEC	ICGC	PGTPEPT	DEG_SCF_FBW7_1	0.3056
p.R568P	DO233159	GACA	ICGC	PGTPEPT	DEG_SCF_FBW7_1	0.1111
p.T560I	DO228585	LICA	ICGC	PGTPEPT	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E7EW31	Proline-rich basic protein 1	DEG_SCF_FBW7_1	554:560	PGTPEPT	FBXW7	0.8292	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons