DegronMD - P08047(SP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T322S	TCGA-43-6771	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.T322S	DO26443	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.S728C	TCGA-85-8664	LUSC	TCGA	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation altering degron motif	0.8652
p.S728C	DO45469	LUSC	ICGC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation altering degron motif	0.8652
p.G731S	TCGA-A3-A8OX	KIRC	TCGA	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation altering degron motif	0.5882
p.G731S	DO49690	KIRC	ICGC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation altering degron motif	0.5882
p.A513V	TCGA-AA-3664	COAD	TCGA	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1667
p.A513V	DO7831	COAD	ICGC	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1667
p.A742T	TCGA-AX-A1CE	UCEC	TCGA	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.0556
p.A742T	DO42280	UCEC	ICGC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.0556
p.Q494H	TCGA-AZ-6601	COAD	TCGA	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1111
p.Q494H	DO8119	COAD	ICGC	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1111
p.A308T	TCGA-BR-7851	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.1389
p.A308T	DO38711	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.1389
p.L502V	TCGA-BR-8080	STAD	TCGA	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.5654
p.L502V	DO38651	STAD	ICGC	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.5654
p.L502V	SIDM00987	Thyroid Gland Carcinoma	GDSC	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.5654
p.L502V	ACH-000191	Thyroid Cancer	CCLE	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.5654
p.L502V	BHT-101	thyroid	COSMIC	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.5654
p.G736S	TCGA-D1-A103	UCEC	TCGA	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.2222
p.G736S	DO42312	UCEC	ICGC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.2222
p.T49A	TCGA-FI-A2D5	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	38:42	Mutation blocking phosphorylation signal	0.5833
p.T49A	DO41331	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	38:42	Mutation blocking phosphorylation signal	0.5833
p.S496T	TCGA-SJ-A6ZI	UCEC	TCGA	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1667
p.S496T	DO219784	UCEC	ICGC	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1667
p.S36L	DO48368	BLCA	ICGC	ARSSS	DEG_SPOP_SBC_1	38:42	Mutation blocking phosphorylation signal	0.7222
p.S46C	DO227949	BRCA	ICGC	ARSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2222
p.A738G	DO222492	COCA	ICGC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.1667
p.S496N	DO233935	GACA	ICGC	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1667
p.A513S	DO229022	LICA	ICGC	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1667
p.V717I	DO229177	LMS	ICGC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.0556
p.F35L	DO35242	PACA	ICGC	ARSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.25
p.T737A	SIDM00373	Endometrial Carcinoma	GDSC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation blocking phosphorylation signal	0.6389
p.T737A	SIDM00469	Pancreatic Carcinoma	GDSC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation blocking phosphorylation signal	0.6389
p.T737A	SIDM01446	Glioblastoma	GDSC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation blocking phosphorylation signal	0.6389
p.Q314H	SIDM01021	Glioblastoma	GDSC	ASSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.3056
p.G736V	SIDM00319	Melanoma	GDSC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.2222
p.G736V	ACH-001704	Skin Cancer	CCLE	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.2222
p.G736V	VMRC-MELG	skin	COSMIC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.2222
p.A738T	SIDM01087	Melanoma	GDSC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.1667
p.A738T	ACH-000348	Skin Cancer	CCLE	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.1667
p.A738T	RPMI-7951	skin	COSMIC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation rewiring degron network	0.1667
p.V311L	ACH-000787	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.2222
p.V311L	LXF-289	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.2222
p.L492V	ACH-000844	Lung Cancer	CCLE	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.0556
p.G44S	ACH-001807	Liposarcoma	CCLE	ARSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2778
p.A731T	RPMI-7951	skin	COSMIC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation altering degron motif	0.7139
p.S327N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.1111
p.G729V	VMRC-MELG	skin	COSMIC	DSGAGS	DEG_SCF_TRCP1_1	727:732	Mutation altering degron motif	0.7532
p.L495V	BHT-101	thyroid	COSMIC	LTPIAS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1389

Kaplan plot for SP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SP1

UniProt ID: P08047

Entrez ID: 6667

Protein name: Transcription factor Sp1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SP1 in