DegronMD

Uniprot ID: P08047

Source protein: Transcription factor Sp1

Source gene: SP1

Class: DEG_SCF_FBW7_1

Location: 502:507

E3 ligase: FBXW7

DEGRON score: 0.9934

ASA_SCORE: 72.4667

COIL: 0.8077

CONS_SCORE: 0.3294

DSS_SCORE: 0.3988

HELIX: 0.0582

FCONS_SCORE: 0.8689

RIG_SCORE: 0.7592

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A513V	TCGA-AA-3664	COAD	TCGA	LTPIAS	DEG_SCF_FBW7_1	0.1667
p.A513V	DO7831	COAD	ICGC	LTPIAS	DEG_SCF_FBW7_1	0.1667
p.Q494H	TCGA-AZ-6601	COAD	TCGA	LTPIAS	DEG_SCF_FBW7_1	0.1111
p.Q494H	DO8119	COAD	ICGC	LTPIAS	DEG_SCF_FBW7_1	0.1111
p.L502V	TCGA-BR-8080	STAD	TCGA	LTPIAS	DEG_SCF_FBW7_1	0.5654
p.L502V	DO38651	STAD	ICGC	LTPIAS	DEG_SCF_FBW7_1	0.5654
p.L502V	SIDM00987	Thyroid Gland Carcinoma	GDSC	LTPIAS	DEG_SCF_FBW7_1	0.5654
p.L502V	ACH-000191	Thyroid Cancer	CCLE	LTPIAS	DEG_SCF_FBW7_1	0.5654
p.L502V	BHT-101	thyroid	COSMIC	LTPIAS	DEG_SCF_FBW7_1	0.5654
p.S496T	TCGA-SJ-A6ZI	UCEC	TCGA	LTPIAS	DEG_SCF_FBW7_1	0.1667
p.S496T	DO219784	UCEC	ICGC	LTPIAS	DEG_SCF_FBW7_1	0.1667
p.S496N	DO233935	GACA	ICGC	LTPIAS	DEG_SCF_FBW7_1	0.1667
p.A513S	DO229022	LICA	ICGC	LTPIAS	DEG_SCF_FBW7_1	0.1667
p.L492V	ACH-000844	Lung Cancer	CCLE	LTPIAS	DEG_SCF_FBW7_1	0.0556
p.L495V	BHT-101	thyroid	COSMIC	LTPIAS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08047	Transcription factor Sp1	DEG_SCF_FBW7_1	502:507	LTPIAS	FBXW7	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons