DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSGAGS
Uniprot ID:
P08047
Source protein:
Transcription factor Sp1
Source gene:
SP1
Class:
DEG_SCF_TRCP1_1
Location:
727:732
E3 ligase:
BTRC
DEGRON score:
0.9927
ASA_SCORE:
67.4
COIL:
0.9085
CONS_SCORE:
0.3202
DSS_SCORE:
0.5144
HELIX:
0.0603
FCONS_SCORE:
0.9943
RIG_SCORE:
0.6102
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S728C
TCGA-85-8664
LUSC
TCGA
DSGAGS
DEG_SCF_TRCP1_1
0.8652
p.S728C
DO45469
LUSC
ICGC
DSGAGS
DEG_SCF_TRCP1_1
0.8652
p.G731S
TCGA-A3-A8OX
KIRC
TCGA
DSGAGS
DEG_SCF_TRCP1_1
0.5882
p.G731S
DO49690
KIRC
ICGC
DSGAGS
DEG_SCF_TRCP1_1
0.5882
p.A742T
TCGA-AX-A1CE
UCEC
TCGA
DSGAGS
DEG_SCF_TRCP1_1
0.0556
p.A742T
DO42280
UCEC
ICGC
DSGAGS
DEG_SCF_TRCP1_1
0.0556
p.G736S
TCGA-D1-A103
UCEC
TCGA
DSGAGS
DEG_SCF_TRCP1_1
0.2222
p.G736S
DO42312
UCEC
ICGC
DSGAGS
DEG_SCF_TRCP1_1
0.2222
p.A738G
DO222492
COCA
ICGC
DSGAGS
DEG_SCF_TRCP1_1
0.1667
p.V717I
DO229177
LMS
ICGC
DSGAGS
DEG_SCF_TRCP1_1
0.0556
p.T737A
SIDM00373
Endometrial Carcinoma
GDSC
DSGAGS
DEG_SCF_TRCP1_1
0.6389
p.T737A
SIDM00469
Pancreatic Carcinoma
GDSC
DSGAGS
DEG_SCF_TRCP1_1
0.6389
p.T737A
SIDM01446
Glioblastoma
GDSC
DSGAGS
DEG_SCF_TRCP1_1
0.6389
p.G736V
SIDM00319
Melanoma
GDSC
DSGAGS
DEG_SCF_TRCP1_1
0.2222
p.G736V
ACH-001704
Skin Cancer
CCLE
DSGAGS
DEG_SCF_TRCP1_1
0.2222
p.G736V
VMRC-MELG
skin
COSMIC
DSGAGS
DEG_SCF_TRCP1_1
0.2222
p.A738T
SIDM01087
Melanoma
GDSC
DSGAGS
DEG_SCF_TRCP1_1
0.1667
p.A738T
ACH-000348
Skin Cancer
CCLE
DSGAGS
DEG_SCF_TRCP1_1
0.1667
p.A738T
RPMI-7951
skin
COSMIC
DSGAGS
DEG_SCF_TRCP1_1
0.1667
p.A731T
RPMI-7951
skin
COSMIC
DSGAGS
DEG_SCF_TRCP1_1
0.7139
p.G729V
VMRC-MELG
skin
COSMIC
DSGAGS
DEG_SCF_TRCP1_1
0.7532
Drug responses associated with SP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGAGS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P08047
Transcription factor Sp1
DEG_SCF_TRCP1_1
727:732
DSGAGS
BTRC
0.9927
More...