DegronMD - P41594(GRM5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1176R	TCGA-24-1422	OV	TCGA	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation altering degron motif	0.7568
p.S1167F	TCGA-A5-A2K3	UCEC	TCGA	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.1389
p.A1188V	TCGA-A6-3808	COAD	TCGA	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.0833
p.S1187P	TCGA-CV-A6K1	HNSC	TCGA	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.1111
p.D1171N	TCGA-EB-A24D	SKCM	TCGA	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.25
p.S1053L	TCGA-EO-A22U	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.3056
p.S1172L	TCGA-FU-A3HZ	CESC	TCGA	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.2778
p.D1174A	TCGA-GN-A4U5	SKCM	TCGA	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation altering degron motif	0.7793
p.D1174N	TCGA-GN-A4U5	SKCM	TCGA	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation altering degron motif	0.6932
p.T1167I	DO590	BLCA	ICGC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.1389
p.C1062F	DO9482	COAD	ICGC	ARSSS	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.0556
p.S1179L	DO7962	COAD	ICGC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation altering degron motif	0.7667
p.S1179L	DO222557	MELA	ICGC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation altering degron motif	0.7667
p.S1179L	DO47985	STAD	ICGC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation altering degron motif	0.7667
p.S1054G	DO234320	ESAD	ICGC	ARSSS	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.2778
p.G1056S	DO233888	GACA	ICGC	ARSSS	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.2222
p.L1043H	DO14918	HNSC	ICGC	ARSSS	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1944
p.N1044K	DO228978	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.2222
p.T1174N	DO229031	LICA	ICGC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation altering degron motif	0.7055
p.S1054C	DO52331	LIHC	ICGC	ARSSS	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.2778
p.D1172G	DO50834	LIRI	ICGC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.2778
p.Q1175L	DO231165	LUSC	ICGC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation altering degron motif	0.7765
p.A1051V	DO41331	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	1048:1052	Mutation altering degron motif	0.6936
p.P1183T	SIDM01307	Colorectal Carcinoma	GDSC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.2222
p.P1183L	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.2222
p.P1183L	ACH-000583	Lymphoma	CCLE	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.2222
p.P1183L	MC116	haematopoietic and lymphoid tissue	COSMIC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.2222
p.D1171E	SIDM00112	Kidney Carcinoma	GDSC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.25
p.D1171E	ACH-000428	Kidney Cancer	CCLE	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.25
p.D1171E	U031	kidney	COSMIC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.25
p.P1180H	SIDM00901	Endometrial Carcinoma	GDSC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.3056
p.P1180H	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.3056
p.P1180H	AN3-CA	endometrium	COSMIC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.3056
p.L1168P	NB12	autonomic ganglia	COSMIC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.1667
p.L1168P	IGR-1	skin	COSMIC	DSGSTT	DEG_SCF_TRCP1_1	1174:1179	Mutation rewiring degron network	0.1667

Kaplan plot for GRM5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRM5

UniProt ID: P41594

Entrez ID: 2915

Protein name: Metabotropic glutamate receptor 5 (mGluR5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRM5 in