DegronMD

Uniprot ID: P41594

Source protein: Metabotropic glutamate receptor 5

Source gene: GRM5

Class: DEG_SCF_TRCP1_1

Location: 1174:1179

E3 ligase: BTRC

DEGRON score: 0.9628

ASA_SCORE: 74.0667

COIL: 0.901

CONS_SCORE: 0.2597

DSS_SCORE: 0.6517

HELIX: 0.0628

FCONS_SCORE: 0.9957

RIG_SCORE: 0.5558

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1176R	TCGA-24-1422	OV	TCGA	DSGSTT	DEG_SCF_TRCP1_1	0.7568
p.S1167F	TCGA-A5-A2K3	UCEC	TCGA	DSGSTT	DEG_SCF_TRCP1_1	0.1389
p.A1188V	TCGA-A6-3808	COAD	TCGA	DSGSTT	DEG_SCF_TRCP1_1	0.0833
p.S1187P	TCGA-CV-A6K1	HNSC	TCGA	DSGSTT	DEG_SCF_TRCP1_1	0.1111
p.D1171N	TCGA-EB-A24D	SKCM	TCGA	DSGSTT	DEG_SCF_TRCP1_1	0.25
p.S1172L	TCGA-FU-A3HZ	CESC	TCGA	DSGSTT	DEG_SCF_TRCP1_1	0.2778
p.D1174A	TCGA-GN-A4U5	SKCM	TCGA	DSGSTT	DEG_SCF_TRCP1_1	0.7793
p.D1174N	TCGA-GN-A4U5	SKCM	TCGA	DSGSTT	DEG_SCF_TRCP1_1	0.6932
p.T1167I	DO590	BLCA	ICGC	DSGSTT	DEG_SCF_TRCP1_1	0.1389
p.S1179L	DO7962	COAD	ICGC	DSGSTT	DEG_SCF_TRCP1_1	0.7667
p.S1179L	DO222557	MELA	ICGC	DSGSTT	DEG_SCF_TRCP1_1	0.7667
p.S1179L	DO47985	STAD	ICGC	DSGSTT	DEG_SCF_TRCP1_1	0.7667
p.T1174N	DO229031	LICA	ICGC	DSGSTT	DEG_SCF_TRCP1_1	0.7055
p.D1172G	DO50834	LIRI	ICGC	DSGSTT	DEG_SCF_TRCP1_1	0.2778
p.Q1175L	DO231165	LUSC	ICGC	DSGSTT	DEG_SCF_TRCP1_1	0.7765
p.P1183T	SIDM01307	Colorectal Carcinoma	GDSC	DSGSTT	DEG_SCF_TRCP1_1	0.2222
p.P1183L	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGSTT	DEG_SCF_TRCP1_1	0.2222
p.P1183L	ACH-000583	Lymphoma	CCLE	DSGSTT	DEG_SCF_TRCP1_1	0.2222
p.P1183L	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSTT	DEG_SCF_TRCP1_1	0.2222
p.D1171E	SIDM00112	Kidney Carcinoma	GDSC	DSGSTT	DEG_SCF_TRCP1_1	0.25
p.D1171E	ACH-000428	Kidney Cancer	CCLE	DSGSTT	DEG_SCF_TRCP1_1	0.25
p.D1171E	U031	kidney	COSMIC	DSGSTT	DEG_SCF_TRCP1_1	0.25
p.P1180H	SIDM00901	Endometrial Carcinoma	GDSC	DSGSTT	DEG_SCF_TRCP1_1	0.3056
p.P1180H	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGSTT	DEG_SCF_TRCP1_1	0.3056
p.P1180H	AN3-CA	endometrium	COSMIC	DSGSTT	DEG_SCF_TRCP1_1	0.3056
p.L1168P	NB12	autonomic_ganglia	COSMIC	DSGSTT	DEG_SCF_TRCP1_1	0.1667
p.L1168P	IGR-1	skin	COSMIC	DSGSTT	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41594	Metabotropic glutamate receptor 5	DEG_SCF_TRCP1_1	1174:1179	DSGSTT	BTRC	0.9628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSTT

Degron related mutations and impact score

Drug responses associated with GRM5 mutations

All proteins holding degron of DSGSTT