DegronMD - Q96AY4(TTC28)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A2381S	TCGA-DI-A1BU	UCEC	TCGA	KRDVLSLLN	DEG_APCC_DBOX_1	2388:2396	Mutation rewiring degron network	0.1389
p.A2381S	DO42023	UCEC	ICGC	KRDVLSLLN	DEG_APCC_DBOX_1	2388:2396	Mutation rewiring degron network	0.1389
p.A2213V	TCGA-FI-A2D5	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	2199:2203	Mutation rewiring degron network	0.0556
p.A2213V	DO48682	LIRI	ICGC	APSST	DEG_SPOP_SBC_1	2199:2203	Mutation rewiring degron network	0.0556
p.A2213V	DO41331	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	2199:2203	Mutation rewiring degron network	0.0556
p.S2136L	TCGA-VS-A9UV	CESC	TCGA	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation blocking phosphorylation signal	0.75
p.S2136L	DO219741	CESC	ICGC	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation blocking phosphorylation signal	0.75
p.P2236T	DO227996	COCA	ICGC	ARSSS	DEG_SPOP_SBC_1	2237:2241	Mutation rewiring degron network	0.3056
p.R2400W	DO227996	COCA	ICGC	KRDVLSLLN	DEG_APCC_DBOX_1	2388:2396	Mutation rewiring degron network	0.2222
p.P26T	DO229010	COCA	ICGC	PTPARS	DEG_SCF_FBW7_1	15:20	Mutation rewiring degron network	0.1667
p.P26T	DO229013	COCA	ICGC	PTPARS	DEG_SCF_FBW7_1	15:20	Mutation rewiring degron network	0.1667
p.P26T	DO229005	COCA	ICGC	PTPARS	DEG_SCF_FBW7_1	15:20	Mutation rewiring degron network	0.1667
p.P26T	DO229057	LICA	ICGC	PTPARS	DEG_SCF_FBW7_1	15:20	Mutation rewiring degron network	0.1667
p.T12A	DO229005	COCA	ICGC	PTPARS	DEG_SCF_FBW7_1	15:20	Mutation blocking phosphorylation signal	0.6944
p.V2229F	DO50990	LAML	ICGC	ARSSS	DEG_SPOP_SBC_1	2237:2241	Mutation rewiring degron network	0.1111
p.S2201R	DO229019	LICA	ICGC	APSST	DEG_SPOP_SBC_1	2199:2203	Mutation altering degron motif	0.7427
p.D2137E	DO229037	LICA	ICGC	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation rewiring degron network	0.2778
p.A2199E	DO229009	LICA	ICGC	APSST	DEG_SPOP_SBC_1	2199:2203	Mutation altering degron motif	0.7701
p.N2396T	DO222632	MELA	ICGC	KRDVLSLLN	DEG_APCC_DBOX_1	2388:2396	Mutation altering degron motif	0.5944
p.Q2198R	DO232018	ORCA	ICGC	APSST	DEG_SPOP_SBC_1	2199:2203	Mutation rewiring degron network	0.3056
p.K2403N	DO232761	PBCA	ICGC	KRDVLSLLN	DEG_APCC_DBOX_1	2388:2396	Mutation substituting flanking lysine	0.25
p.R2379W	SIDM01289	Esophageal Carcinoma	GDSC	KRDVLSLLN	DEG_APCC_DBOX_1	2388:2396	Mutation rewiring degron network	0.0833
p.R2379W	ACH-001329	Brain Cancer	CCLE	KRDVLSLLN	DEG_APCC_DBOX_1	2388:2396	Mutation rewiring degron network	0.0833
p.G2248R	SIDM00120	Prostate Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	2237:2241	Mutation rewiring degron network	0.1389
p.G2248R	DU-145	prostate	COSMIC	ARSSS	DEG_SPOP_SBC_1	2237:2241	Mutation rewiring degron network	0.1389
p.A2129E	SIDM00482	Chronic Myelogenous Leukemia	GDSC	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation rewiring degron network	0.3056
p.A2129E	ACH-002302	Leukemia	CCLE	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation rewiring degron network	0.3056
p.A2129E	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation rewiring degron network	0.3056
p.F2122L	SIDM00557	Neuroblastoma	GDSC	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation rewiring degron network	0.1111
p.F2122L	ACH-000345	Neuroblastoma	CCLE	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation rewiring degron network	0.1111
p.F2122L	KP-N-RT-BM-1	autonomic ganglia	COSMIC	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation rewiring degron network	0.1111
p.T2143M	SIDM01049	Non-Cancerous	GDSC	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation rewiring degron network	0.1111
p.T2143M	ACH-000038	Lymphoma	CCLE	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation rewiring degron network	0.1111
p.T2143M	EHEB	haematopoietic and lymphoid tissue	COSMIC	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation rewiring degron network	0.1111
p.N2402S	SIDM00954	Breast Carcinoma	GDSC	KRDVLSLLN	DEG_APCC_DBOX_1	2388:2396	Mutation rewiring degron network	0.1667
p.S2246T	ACH-002005	Skin Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	2237:2241	Mutation rewiring degron network	0.1944
p.A27T	HCT-15	large intestine	COSMIC	PTPARS	DEG_SCF_FBW7_1	15:20	Mutation rewiring degron network	0.1389
p.A2229T	SNU-C2B	large intestine	COSMIC	ARSSS	DEG_SPOP_SBC_1	2237:2241	Mutation rewiring degron network	0.1111
p.A20E	ABC-1	lung	COSMIC	PTPARS	DEG_SCF_FBW7_1	15:20	Mutation altering degron motif	0.7701
p.Q2228K	MC116	haematopoietic and lymphoid tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	2237:2241	Mutation rewiring degron network	0.0833
p.G2121R	DU-145	prostate	COSMIC	SSDTGE	DEG_Kelch_Keap1_1	2130:2135	Mutation rewiring degron network	0.0833
p.A16V	MZ7-mel	skin	COSMIC	PTPARS	DEG_SCF_FBW7_1	15:20	Mutation altering degron motif	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTC28

UniProt ID: Q96AY4

Entrez ID: 23331

Protein name: Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTC28 in