DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
KRDVLSLLN
Uniprot ID:
Q96AY4
Source protein:
Tetratricopeptide repeat protein 28
Source gene:
TTC28
Class:
DEG_APCC_DBOX_1
Location:
2388:2396
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9084
ASA_SCORE:
61.5111
COIL:
0.3989
CONS_SCORE:
0.3
DSS_SCORE:
0.5147
HELIX:
0.4269
FCONS_SCORE:
1.1524
RIG_SCORE:
0.775
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A2381S
TCGA-DI-A1BU
UCEC
TCGA
KRDVLSLLN
DEG_APCC_DBOX_1
0.1389
p.A2381S
DO42023
UCEC
ICGC
KRDVLSLLN
DEG_APCC_DBOX_1
0.1389
p.R2400W
DO227996
COCA
ICGC
KRDVLSLLN
DEG_APCC_DBOX_1
0.2222
p.N2396T
DO222632
MELA
ICGC
KRDVLSLLN
DEG_APCC_DBOX_1
0.5944
p.K2403N
DO232761
PBCA
ICGC
KRDVLSLLN
DEG_APCC_DBOX_1
0.25
p.R2379W
SIDM01289
Esophageal Carcinoma
GDSC
KRDVLSLLN
DEG_APCC_DBOX_1
0.0833
p.R2379W
ACH-001329
Brain Cancer
CCLE
KRDVLSLLN
DEG_APCC_DBOX_1
0.0833
p.N2402S
SIDM00954
Breast Carcinoma
GDSC
KRDVLSLLN
DEG_APCC_DBOX_1
0.1667
Drug responses associated with TTC28 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KRDVLSLLN
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96AY4
Tetratricopeptide repeat protein 28
DEG_APCC_DBOX_1
2388:2396
KRDVLSLLN
APC,CDC20,FZR1
0.9084
More...