DegronMD

Uniprot ID: Q96AY4

Source protein: Tetratricopeptide repeat protein 28

Source gene: TTC28

Class: DEG_SCF_FBW7_1

Location: 15:20

E3 ligase: FBXW7

DEGRON score: 0.9912

ASA_SCORE: 88.9333

COIL: 0.8235

CONS_SCORE: 0.2448

DSS_SCORE: 0.9181

HELIX: 0.1437

FCONS_SCORE: 1.0305

RIG_SCORE: 0.5456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P26T	DO229010	COCA	ICGC	PTPARS	DEG_SCF_FBW7_1	0.1667
p.P26T	DO229013	COCA	ICGC	PTPARS	DEG_SCF_FBW7_1	0.1667
p.P26T	DO229005	COCA	ICGC	PTPARS	DEG_SCF_FBW7_1	0.1667
p.P26T	DO229057	LICA	ICGC	PTPARS	DEG_SCF_FBW7_1	0.1667
p.T12A	DO229005	COCA	ICGC	PTPARS	DEG_SCF_FBW7_1	0.6944
p.A27T	HCT-15	large_intestine	COSMIC	PTPARS	DEG_SCF_FBW7_1	0.1389
p.A20E	ABC-1	lung	COSMIC	PTPARS	DEG_SCF_FBW7_1	0.7701
p.A16V	MZ7-mel	skin	COSMIC	PTPARS	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AY4	Tetratricopeptide repeat protein 28	DEG_SCF_FBW7_1	15:20	PTPARS	FBXW7	0.9912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons