DegronMD

Uniprot ID: Q96AY4

Source protein: Tetratricopeptide repeat protein 28

Source gene: TTC28

Class: DEG_Kelch_Keap1_1

Location: 2130:2135

E3 ligase: KEAP1

DEGRON score: 0.985

ASA_SCORE: 94.2833

COIL: 0.9267

CONS_SCORE: 0.2881

DSS_SCORE: 0.6884

HELIX: 0.0465

FCONS_SCORE: 1.0898

RIG_SCORE: 0.564

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2136L	TCGA-VS-A9UV	CESC	TCGA	SSDTGE	DEG_Kelch_Keap1_1	0.75
p.S2136L	DO219741	CESC	ICGC	SSDTGE	DEG_Kelch_Keap1_1	0.75
p.D2137E	DO229037	LICA	ICGC	SSDTGE	DEG_Kelch_Keap1_1	0.2778
p.A2129E	SIDM00482	Chronic Myelogenous Leukemia	GDSC	SSDTGE	DEG_Kelch_Keap1_1	0.3056
p.A2129E	ACH-002302	Leukemia	CCLE	SSDTGE	DEG_Kelch_Keap1_1	0.3056
p.A2129E	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	SSDTGE	DEG_Kelch_Keap1_1	0.3056
p.F2122L	SIDM00557	Neuroblastoma	GDSC	SSDTGE	DEG_Kelch_Keap1_1	0.1111
p.F2122L	ACH-000345	Neuroblastoma	CCLE	SSDTGE	DEG_Kelch_Keap1_1	0.1111
p.F2122L	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	SSDTGE	DEG_Kelch_Keap1_1	0.1111
p.T2143M	SIDM01049	Non-Cancerous	GDSC	SSDTGE	DEG_Kelch_Keap1_1	0.1111
p.T2143M	ACH-000038	Lymphoma	CCLE	SSDTGE	DEG_Kelch_Keap1_1	0.1111
p.T2143M	EHEB	haematopoietic_and_lymphoid_tissue	COSMIC	SSDTGE	DEG_Kelch_Keap1_1	0.1111
p.G2121R	DU-145	prostate	COSMIC	SSDTGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AY4	Tetratricopeptide repeat protein 28	DEG_Kelch_Keap1_1	2130:2135	SSDTGE	KEAP1	0.985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons