DegronMD - P0C1S8(WEE2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R563C	TCGA-A5-A0G1	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1667
p.R563C	TCGA-IB-7651	PAAD	TCGA	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1667
p.R563C	DO46657	PAAD	ICGC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1667
p.R563C	DO42472	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1667
p.K551N	TCGA-AJ-A3EL	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.K551N	DO41542	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.E564D	TCGA-AP-A051	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1389
p.E564D	DO42673	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1389
p.R563H	TCGA-D1-A15X	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1667
p.R563H	DO43274	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1667
p.G550E	TCGA-EE-A29D	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.25
p.G550E	DO38123	SKCM	ICGC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.25
p.S556L	TCGA-Q1-A73O	CESC	TCGA	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7667
p.S556L	DO51612	CESC	ICGC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7667
p.K545N	DO225353	BRCA	ICGC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation substituting flanking lysine	0.2222
p.K545N	DO222884	COCA	ICGC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation substituting flanking lysine	0.2222
p.S557R	DO229259	THCA	ICGC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7427
p.T559S	SIDM00973	Melanoma	GDSC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.T559S	ACH-000827	Skin Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.T559S	WM793B	skin	COSMIC	ARSSS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778

Kaplan plot for WEE2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WEE2

UniProt ID: P0C1S8

Entrez ID: 494551

Protein name: Wee1-like protein kinase 2 (EC 2.7.10.2) (Wee1-like protein kinase 1B) (Wee1B kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WEE2 in