DegronMD - Q7Z591(AKNA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A918V	TCGA-55-8089	LUAD	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	923:929	Mutation rewiring degron network	0.1944
p.A918V	TCGA-AX-A2HC	UCEC	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	923:929	Mutation rewiring degron network	0.1944
p.A918V	SIDM00989	Bladder Carcinoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	923:929	Mutation rewiring degron network	0.1944
p.A918V	BFTC-905	urinary tract	COSMIC	DSGFVGS	DEG_SCF_TRCP1_1	923:929	Mutation rewiring degron network	0.1944
p.F476L	TCGA-A5-A1OF	UCEC	TCGA	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.6981
p.F476L	DO42568	UCEC	ICGC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.6981
p.T488M	TCGA-AP-A059	UCEC	TCGA	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.0556
p.T488M	DO233867	GACA	ICGC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.0556
p.T488M	DO41361	UCEC	ICGC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.0556
p.P920T	TCGA-BF-A1Q0	SKCM	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	923:929	Mutation rewiring degron network	0.25
p.S1160F	TCGA-D3-A3MR	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	1157:1161	Mutation altering degron motif	0.9093
p.E96Q	TCGA-DK-A6B6	BLCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.0833
p.E96Q	DO48576	BLCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.0833
p.E1185Q	TCGA-E2-A1LG	BRCA	TCGA	LPLFSE	LIG_APCC_ABBA_1	1180:1185	Mutation altering degron motif	0.6744
p.E1410K	TCGA-E7-A6MD	BLCA	TCGA	VRSTT	DEG_SPOP_SBC_1	1412:1416	Mutation rewiring degron network	0.2778
p.E1410K	TCGA-GM-A2DO	BRCA	TCGA	VRSTT	DEG_SPOP_SBC_1	1412:1416	Mutation rewiring degron network	0.2778
p.M1419I	TCGA-EE-A2MG	SKCM	TCGA	VRSTT	DEG_SPOP_SBC_1	1412:1416	Mutation rewiring degron network	0.25
p.G86V	TCGA-EM-A2CN	THCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7532
p.G86V	DO39886	THCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7532
p.P1151H	TCGA-FS-A1ZR	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.1667
p.S935L	TCGA-GU-AATO	BLCA	TCGA	DSGFVGS	DEG_SCF_TRCP1_1	923:929	Mutation rewiring degron network	0.1667
p.D97N	TCGA-UY-A78K	BLCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.0556
p.D97N	DO219031	BLCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.0556
p.S85L	TCGA-YC-A89H	BLCA	TCGA	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.8778
p.S85L	DO51948	BLCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.8778
p.G87S	DO51883	BLCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.6993
p.P84L	DO222990	BTCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO227999	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO229010	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO229016	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO229003	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO229005	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO229353	LAML	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO230659	LAML	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO228941	LICA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO229028	LICA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO229047	LICA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO52365	LUSC	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.P84L	DO231036	LUSC	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7582
p.E91D	DO229013	COCA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.2222
p.E91D	SIDM00305	Ovarian Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.2222
p.E91D	SIDM00555	Glioblastoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.2222
p.E91D	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.2222
p.E91D	SIDM01196	Hepatocellular Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.2222
p.E91D	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.2222
p.E91D	SIDM01770	Gastric Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.2222
p.E91D	SNU-475	liver	COSMIC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.2222
p.E91D	KS-1	central nervous system	COSMIC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.2222
p.E91D	TE-1	oesophagus	COSMIC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.2222
p.S88Y	DO44440	HNSC	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.3056
p.H74N	DO229006	LICA	ICGC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.1111
p.Q466K	DO229008	LICA	ICGC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1389
p.A466E	DO41959	UCEC	ICGC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1389
p.E478K	DO42753	UCEC	ICGC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.7022
p.R473Q	DO42633	UCEC	ICGC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.7329
p.R473Q	JHOS-4	ovary	COSMIC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.7329
p.R473Q	KMH-2	thyroid	COSMIC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.7329
p.E84K	SIDM00216	Colorectal Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7022
p.E84K	ACH-000989	Colon/Colorectal Cancer	CCLE	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.7022
p.S485N	SIDM01117	Small Cell Lung Carcinoma	GDSC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1389
p.H484Y	SIDM00722	Mesothelioma	GDSC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1667
p.H484Y	ACH-000092	Lung Cancer	CCLE	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1667
p.H484Y	NCI-H2452	pleura	COSMIC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1667
p.P1152L	SIDM00120	Prostate Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.1944
p.P1152L	ACH-000979	Prostate Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.1944
p.P1152L	DU-145	prostate	COSMIC	ARSSS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.1944
p.E914K	SIDM00255	Neuroblastoma	GDSC	DSGFVGS	DEG_SCF_TRCP1_1	923:929	Mutation rewiring degron network	0.0833
p.E914K	NB17	autonomic ganglia	COSMIC	DSGFVGS	DEG_SCF_TRCP1_1	923:929	Mutation rewiring degron network	0.0833
p.V1412I	SIDM00227	Neuroblastoma	GDSC	VRSTT	DEG_SPOP_SBC_1	1412:1416	Mutation altering degron motif	0.7076
p.V1412I	GI-ME-N	autonomic ganglia	COSMIC	VRSTT	DEG_SPOP_SBC_1	1412:1416	Mutation altering degron motif	0.7076
p.V473L	SIDM00396	Acute Myeloid Leukemia	GDSC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.5654
p.V473L	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.5654
p.S1184F	SIDM00172	Head and Neck Carcinoma	GDSC	LPLFSE	LIG_APCC_ABBA_1	1180:1185	Mutation altering degron motif	0.6871
p.S1184F	ACH-002212	Head and Neck Cancer	CCLE	LPLFSE	LIG_APCC_ABBA_1	1180:1185	Mutation altering degron motif	0.6871
p.S1184F	BB30-HNC	upper aerodigestive tract	COSMIC	LPLFSE	LIG_APCC_ABBA_1	1180:1185	Mutation altering degron motif	0.6871
p.K1191E	SIDM01146	Gastric Carcinoma	GDSC	LPLFSE	LIG_APCC_ABBA_1	1180:1185	Mutation substituting flanking lysine	0.2778
p.K1191E	NCI-SNU-1	stomach	COSMIC	LPLFSE	LIG_APCC_ABBA_1	1180:1185	Mutation substituting flanking lysine	0.2778
p.F1183L	SIDM01146	Gastric Carcinoma	GDSC	LPLFSE	LIG_APCC_ABBA_1	1180:1185	Mutation altering degron motif	0.6981
p.F1183L	ACH-000932	Gastric Cancer	CCLE	LPLFSE	LIG_APCC_ABBA_1	1180:1185	Mutation altering degron motif	0.6981
p.F1183L	NCI-SNU-1	stomach	COSMIC	LPLFSE	LIG_APCC_ABBA_1	1180:1185	Mutation altering degron motif	0.6981
p.A1405V	SIDM00438	B-Lymphoblastic Leukemia	GDSC	VRSTT	DEG_SPOP_SBC_1	1412:1416	Mutation rewiring degron network	0.1389
p.A1405V	ACH-002275	Leukemia	CCLE	VRSTT	DEG_SPOP_SBC_1	1412:1416	Mutation rewiring degron network	0.1389
p.A1405V	MN-60	haematopoietic and lymphoid tissue	COSMIC	VRSTT	DEG_SPOP_SBC_1	1412:1416	Mutation rewiring degron network	0.1389
p.P482S	SIDM00438	B-Lymphoblastic Leukemia	GDSC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.2222
p.P482S	MN-60	haematopoietic and lymphoid tissue	COSMIC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.2222
p.D478G	SIDM00217	Colorectal Carcinoma	GDSC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.7198
p.D478G	ACH-000999	Colon/Colorectal Cancer	CCLE	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.7198
p.D478G	SNU-1040	large intestine	COSMIC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.7198
p.E92D	SIDM01608	Endometrial Carcinoma	GDSC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.1944
p.S1184P	ACH-000028	Breast Cancer	CCLE	LPLFSE	LIG_APCC_ABBA_1	1180:1185	Mutation altering degron motif	0.5641
p.P75L	ACH-001547	Lung Cancer	CCLE	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.1389
p.P97L	DU-145	prostate	COSMIC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.0556
p.A476T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.7139
p.T1157I	CW-2	large intestine	COSMIC	ARSSS	DEG_SPOP_SBC_1	1157:1161	Mutation altering degron motif	0.7078
p.A935T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DSGFVGS	DEG_SCF_TRCP1_1	923:929	Mutation rewiring degron network	0.1667
p.A86V	OVK-18	ovary	COSMIC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation altering degron motif	0.6936
p.R1164Q	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.25
p.A486T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VNLFSD	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1111
p.R932Q	KMH-2	thyroid	COSMIC	DSGFVGS	DEG_SCF_TRCP1_1	923:929	Mutation rewiring degron network	0.25
p.R932Q	JHOS-4	ovary	COSMIC	DSGFVGS	DEG_SCF_TRCP1_1	923:929	Mutation rewiring degron network	0.25
p.H74R	no-10	central nervous system	COSMIC	DSESGE	DEG_Kelch_Keap1_1	82:87	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKNA

UniProt ID: Q7Z591

Entrez ID: 80709

Protein name: Microtubule organization protein AKNA (AT-hook-containing transcription factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKNA in