DegronMD

Uniprot ID: Q7Z591

Source protein: Microtubule organization protein AKNA

Source gene: AKNA

Class: DEG_SPOP_SBC_1

Location: 1412:1416

E3 ligase: SPOP

DEGRON score: 0.7681

ASA_SCORE: 58.3

COIL: 0.0586

CONS_SCORE: 0.5139

DSS_SCORE: 0.4786

HELIX: 0.9416

FCONS_SCORE: 1.0616

RIG_SCORE: 0.7259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1410K	TCGA-E7-A6MD	BLCA	TCGA	VRSTT	DEG_SPOP_SBC_1	0.2778
p.E1410K	TCGA-GM-A2DO	BRCA	TCGA	VRSTT	DEG_SPOP_SBC_1	0.2778
p.M1419I	TCGA-EE-A2MG	SKCM	TCGA	VRSTT	DEG_SPOP_SBC_1	0.25
p.V1412I	SIDM00227	Neuroblastoma	GDSC	VRSTT	DEG_SPOP_SBC_1	0.7076
p.V1412I	GI-ME-N	autonomic_ganglia	COSMIC	VRSTT	DEG_SPOP_SBC_1	0.7076
p.A1405V	SIDM00438	B-Lymphoblastic Leukemia	GDSC	VRSTT	DEG_SPOP_SBC_1	0.1389
p.A1405V	ACH-002275	Leukemia	CCLE	VRSTT	DEG_SPOP_SBC_1	0.1389
p.A1405V	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	VRSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z591	Microtubule organization protein AKNA	DEG_SPOP_SBC_1	1412:1416	VRSTT	SPOP	0.7681	More...
Q7Z7M0	Multiple epidermal growth factor-like domains protein 8	DEG_SPOP_SBC_1	703:707	VRSTT	SPOP	0.8408	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons