DegronMD - Q7Z7M0(MEGF8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T713P	TCGA-55-7574	LUAD	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation altering degron motif	0.7031
p.R714Q	TCGA-55-8208	LUAD	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation altering degron motif	0.7329
p.E710K	TCGA-78-7147	LUAD	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation altering degron motif	0.7022
p.L724I	TCGA-AP-A051	UCEC	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation rewiring degron network	0.0833
p.R69Q	TCGA-AP-A1DK	UCEC	TCGA	HRILLDFLF	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.7329
p.R69Q	DO42033	UCEC	ICGC	HRILLDFLF	DEG_APCC_DBOX_1	68:76	Mutation altering degron motif	0.7329
p.P719L	TCGA-B5-A1MX	UCEC	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation rewiring degron network	0.2222
p.R723C	TCGA-B5-A3FC	UCEC	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation rewiring degron network	0.1111
p.A722S	TCGA-CC-A7IK	LIHC	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation rewiring degron network	0.1389
p.T694A	TCGA-DI-A1BU	UCEC	TCGA	VRSTT	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.0833
p.T694A	DO42023	UCEC	ICGC	VRSTT	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.0833
p.R715W	TCGA-E2-A573	BRCA	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation altering degron motif	0.8634
p.R718H	TCGA-E6-A1LX	UCEC	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation rewiring degron network	0.25
p.R718H	TCGA-EW-A1IZ	BRCA	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation rewiring degron network	0.25
p.T694I	TCGA-EE-A2GT	SKCM	TCGA	VRSTT	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.0833
p.T694I	DO37946	SKCM	ICGC	VRSTT	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.0833
p.R704C	TCGA-EO-A22U	UCEC	TCGA	VRSTT	DEG_SPOP_SBC_1	703:707	Mutation altering degron motif	0.719
p.E80K	TCGA-G2-A3VY	BLCA	TCGA	HRILLDFLF	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2222
p.E80K	DO590	BLCA	ICGC	HRILLDFLF	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.2222
p.R715L	TCGA-HU-A4H3	STAD	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation altering degron motif	0.8428
p.T706M	DO9708	COAD	ICGC	VRSTT	DEG_SPOP_SBC_1	703:707	Mutation altering degron motif	0.7423
p.A714S	DO229018	LICA	ICGC	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation altering degron motif	0.6477
p.A63S	DO229045	LICA	ICGC	HRILLDFLF	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1944
p.A714T	DO41361	UCEC	ICGC	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation altering degron motif	0.6028
p.S701L	SIDM00924	Other Solid Cancers	GDSC	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation rewiring degron network	0.1389
p.S701L	SIDM00924	Other Solid Cancers	GDSC	VRSTT	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.2778
p.S701L	ACH-000867	Lung Cancer	CCLE	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation rewiring degron network	0.1389
p.S701L	ACH-000867	Lung Cancer	CCLE	VRSTT	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.2778
p.S701L	ChaGo-K-1	lung	COSMIC	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation rewiring degron network	0.1389
p.S701L	ChaGo-K-1	lung	COSMIC	VRSTT	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.2778
p.C81Y	SIDM00731	Small Cell Lung Carcinoma	GDSC	HRILLDFLF	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1944
p.C81Y	ACH-000399	Lung Cancer	CCLE	HRILLDFLF	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1944
p.C81Y	NCI-H2196	lung	COSMIC	HRILLDFLF	DEG_APCC_DBOX_1	68:76	Mutation rewiring degron network	0.1944
p.R704H	SIDM00245	Small Cell Lung Carcinoma	GDSC	VRSTT	DEG_SPOP_SBC_1	703:707	Mutation altering degron motif	0.7133
p.E715K	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation altering degron motif	0.7022
p.E715K	ACH-002253	Lymphoma	CCLE	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation altering degron motif	0.7022
p.E715K	JSC-1	haematopoietic and lymphoid tissue	COSMIC	ITLTPSAE	DEG_SCF_FBW7_2	708:715	Mutation altering degron motif	0.7022

Kaplan plot for MEGF8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEGF8

UniProt ID: Q7Z7M0

Entrez ID: 1954

Protein name: Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEGF8 in