DegronMD

Uniprot ID: Q7Z7M0

Source protein: Multiple epidermal growth factor-like domains protein 8

Source gene: MEGF8

Class: DEG_APCC_DBOX_1

Location: 68:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6974

ASA_SCORE: 48.1889

COIL: 0.1512

CONS_SCORE: 0.4138

DSS_SCORE: 0.0529

HELIX: 0.0074

FCONS_SCORE: 0.8143

RIG_SCORE: 0.9529

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R69Q	TCGA-AP-A1DK	UCEC	TCGA	HRILLDFLF	DEG_APCC_DBOX_1	0.7329
p.R69Q	DO42033	UCEC	ICGC	HRILLDFLF	DEG_APCC_DBOX_1	0.7329
p.E80K	TCGA-G2-A3VY	BLCA	TCGA	HRILLDFLF	DEG_APCC_DBOX_1	0.2222
p.E80K	DO590	BLCA	ICGC	HRILLDFLF	DEG_APCC_DBOX_1	0.2222
p.A63S	DO229045	LICA	ICGC	HRILLDFLF	DEG_APCC_DBOX_1	0.1944
p.C81Y	SIDM00731	Small Cell Lung Carcinoma	GDSC	HRILLDFLF	DEG_APCC_DBOX_1	0.1944
p.C81Y	ACH-000399	Lung Cancer	CCLE	HRILLDFLF	DEG_APCC_DBOX_1	0.1944
p.C81Y	NCI-H2196	lung	COSMIC	HRILLDFLF	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7M0	Multiple epidermal growth factor-like domains protein 8	DEG_APCC_DBOX_1	68:76	HRILLDFLF	APC,CDC20,FZR1	0.6974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons