DegronMD

Uniprot ID: Q7Z7M0

Source protein: Multiple epidermal growth factor-like domains protein 8

Source gene: MEGF8

Class: DEG_SCF_FBW7_2

Location: 708:715

E3 ligase: FBXW7

DEGRON score: 0.605

ASA_SCORE: 64.8

COIL: 0.6545

CONS_SCORE: 0.3333

DSS_SCORE: 0.2819

HELIX: 0.0316

FCONS_SCORE: 0.9375

RIG_SCORE: 0.7788

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T713P	TCGA-55-7574	LUAD	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	0.7031
p.R714Q	TCGA-55-8208	LUAD	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	0.7329
p.E710K	TCGA-78-7147	LUAD	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	0.7022
p.L724I	TCGA-AP-A051	UCEC	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	0.0833
p.P719L	TCGA-B5-A1MX	UCEC	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	0.2222
p.R723C	TCGA-B5-A3FC	UCEC	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	0.1111
p.A722S	TCGA-CC-A7IK	LIHC	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	0.1389
p.R715W	TCGA-E2-A573	BRCA	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	0.8634
p.R718H	TCGA-E6-A1LX	UCEC	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	0.25
p.R718H	TCGA-EW-A1IZ	BRCA	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	0.25
p.R715L	TCGA-HU-A4H3	STAD	TCGA	ITLTPSAE	DEG_SCF_FBW7_2	0.8428
p.A714S	DO229018	LICA	ICGC	ITLTPSAE	DEG_SCF_FBW7_2	0.6477
p.A714T	DO41361	UCEC	ICGC	ITLTPSAE	DEG_SCF_FBW7_2	0.6028
p.S701L	SIDM00924	Other Solid Cancers	GDSC	ITLTPSAE	DEG_SCF_FBW7_2	0.1389
p.S701L	ACH-000867	Lung Cancer	CCLE	ITLTPSAE	DEG_SCF_FBW7_2	0.1389
p.S701L	ChaGo-K-1	lung	COSMIC	ITLTPSAE	DEG_SCF_FBW7_2	0.1389
p.E715K	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	ITLTPSAE	DEG_SCF_FBW7_2	0.7022
p.E715K	ACH-002253	Lymphoma	CCLE	ITLTPSAE	DEG_SCF_FBW7_2	0.7022
p.E715K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	ITLTPSAE	DEG_SCF_FBW7_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7M0	Multiple epidermal growth factor-like domains protein 8	DEG_SCF_FBW7_2	708:715	ITLTPSAE	FBXW7	0.605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons