DegronMD

Uniprot ID: Q7Z7M0

Source protein: Multiple epidermal growth factor-like domains protein 8

Source gene: MEGF8

Class: DEG_SPOP_SBC_1

Location: 703:707

E3 ligase: SPOP

DEGRON score: 0.8408

ASA_SCORE: 61.84

COIL: 0.437

CONS_SCORE: 0.3488

DSS_SCORE: 0.3967

HELIX: 0.0252

FCONS_SCORE: 0.9196

RIG_SCORE: 0.809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T694A	TCGA-DI-A1BU	UCEC	TCGA	VRSTT	DEG_SPOP_SBC_1	0.0833
p.T694A	DO42023	UCEC	ICGC	VRSTT	DEG_SPOP_SBC_1	0.0833
p.T694I	TCGA-EE-A2GT	SKCM	TCGA	VRSTT	DEG_SPOP_SBC_1	0.0833
p.T694I	DO37946	SKCM	ICGC	VRSTT	DEG_SPOP_SBC_1	0.0833
p.R704C	TCGA-EO-A22U	UCEC	TCGA	VRSTT	DEG_SPOP_SBC_1	0.719
p.T706M	DO9708	COAD	ICGC	VRSTT	DEG_SPOP_SBC_1	0.7423
p.S701L	SIDM00924	Other Solid Cancers	GDSC	VRSTT	DEG_SPOP_SBC_1	0.2778
p.S701L	ACH-000867	Lung Cancer	CCLE	VRSTT	DEG_SPOP_SBC_1	0.2778
p.S701L	ChaGo-K-1	lung	COSMIC	VRSTT	DEG_SPOP_SBC_1	0.2778
p.R704H	SIDM00245	Small Cell Lung Carcinoma	GDSC	VRSTT	DEG_SPOP_SBC_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z591	Microtubule organization protein AKNA	DEG_SPOP_SBC_1	1412:1416	VRSTT	SPOP	0.7681	More...
Q7Z7M0	Multiple epidermal growth factor-like domains protein 8	DEG_SPOP_SBC_1	703:707	VRSTT	SPOP	0.8408	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons