DegronMD

Uniprot ID: Q7Z591

Source protein: Microtubule organization protein AKNA

Source gene: AKNA

Class: LIG_APCC_ABBA_1

Location: 1180:1185

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9907

ASA_SCORE: 96.45

COIL: 0.9217

CONS_SCORE: 0.3877

DSS_SCORE: 0.5825

HELIX: 0.0652

FCONS_SCORE: 0.8216

RIG_SCORE: 0.6882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1185Q	TCGA-E2-A1LG	BRCA	TCGA	LPLFSE	LIG_APCC_ABBA_1	0.6744
p.S1184F	SIDM00172	Head and Neck Carcinoma	GDSC	LPLFSE	LIG_APCC_ABBA_1	0.6871
p.S1184F	ACH-002212	Head and Neck Cancer	CCLE	LPLFSE	LIG_APCC_ABBA_1	0.6871
p.S1184F	BB30-HNC	upper_aerodigestive_tract	COSMIC	LPLFSE	LIG_APCC_ABBA_1	0.6871
p.K1191E	SIDM01146	Gastric Carcinoma	GDSC	LPLFSE	LIG_APCC_ABBA_1	0.2778
p.K1191E	NCI-SNU-1	stomach	COSMIC	LPLFSE	LIG_APCC_ABBA_1	0.2778
p.F1183L	SIDM01146	Gastric Carcinoma	GDSC	LPLFSE	LIG_APCC_ABBA_1	0.6981
p.F1183L	ACH-000932	Gastric Cancer	CCLE	LPLFSE	LIG_APCC_ABBA_1	0.6981
p.F1183L	NCI-SNU-1	stomach	COSMIC	LPLFSE	LIG_APCC_ABBA_1	0.6981
p.S1184P	ACH-000028	Breast Cancer	CCLE	LPLFSE	LIG_APCC_ABBA_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z591	Microtubule organization protein AKNA	LIG_APCC_ABBA_1	1180:1185	LPLFSE	APC,CDC20,FZR1	0.9907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons